Reference Report

Reference
Citation	Duncan, I.W. (2002). Transvection effects in Drosophila. A. Rev. Genet. 36(): 521--556. (Export to RIS)
FlyBase ID	FBrf0151731
Publication Type	Review
PubMed ID	12429702
PubMed Abstract	An unusual feature of the Diptera is that homologous chromosomes are intimately synapsed in somatic cells. At a number of loci in Drosophila, this pairing can significantly influence gene expression. Such influences were first detected within the bithorax complex (BX-C) by E.B. Lewis, who coined the term transvection to describe them. Most cases of transvection involve the action of enhancers in trans. At several loci deletion of the promoter greatly increases this action in trans, suggesting that enhancers are normally tethered in cis by the promoter region. Transvection can also occur by the action of silencers in trans or by the spreading of position effect variegation from rearrangements having heterochromatic breakpoints to paired unrearranged chromosomes. Although not demonstrated, other cases of transvection may involve the production of joint RNAs by trans-splicing. Several cases of transvection require Zeste, a DNA-binding protein that is thought to facilitate homolog interactions by self-aggregation. Genes showing transvection can differ greatly in their response to pairing disruption. In several cases, transvection appears to require intimate synapsis of homologs. However, in at least one case (transvection of the iab-5,6,7 region of the BX-C), transvection is independent of synapsis within and surrounding the interacting gene. The latter example suggests that transvection could well occur in organisms that lack somatic pairing. In support of this, transvection-like phenomena have been described in a number of different organisms, including plants, fungi, and mammals.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	A. Rev. Genet.
Title	Annual Review of Genetics
Publication Year	1967-
ISBN/ISSN	0066-4197
Data from Reference
Aberrations (11)
	Df(3R)Abd-B^S10 Df(3R)RS1-98 Df(3R)ul10 Dp(1;f)1187 Dp(3;1)P115 Dp(3;3)P5 Dp(3;3)P47 Dp(?;2)bw^D In(3LR)iab7^MX2 In(3R)Fab7iab-7^R5 Tp(3;3)bxd¹⁰⁰
Alleles (56)
	abd-A^D24 abd-A^M1 Abd-B^D18 Abd-B^iab6-C7 Abd-B^iab7-MX2 Abd-B^iab8-D14 Abd-B^Mcp-1 Abd-B^PSz-1 Abd-B^PSz-2 Abd-B^S10 Abd-B^Sz bw^D ci¹ dpp^d-ho dpp^hr4 eya² Scr⁴ Scr^W Ubx¹ Ubx^9.22 Ubx^50.1 Ubx^175.1 Ubx¹⁹⁵ Ubx^195rx1 Ubx^abx-1 Ubx^abx-2 Ubx^abx-CAC4 Ubx^bx-1 Ubx^bx-3 Ubx^bx-34e Ubx^bxd-1 Ubx^bxd-51j Ubx^bxd-55i Ubx^bxd-100 Ubx^bxd-K Ubx^Cbx-1 Ubx^Cbx-1RM Ubx^Cbx-2 Ubx^I.7 Ubx^lac1 Ubx^MX6 Ubx^pbx-1 Ubx^pbx-2 w^sp1 y^1#8 y¹ y² y^3c3 y^59b y⁶⁹ y^82f29 y^88d z¹ z^a z^ae(bx) z^op6
Genes (35)
	abd-A Abd-B Abd-B-PTS Adh Ata bw bxd ci dpp en eya Fab-7 Fab-8 Gpdh grh hh iab-8PRE kar MCP-PRE mod(mdg4) Pc piwi pnt Pu Scr Sgs4 Trl trx Ubx UbxPRE vg w wg y z
Natural transposons (1)
	gypsy