Reference Report

Reference
Citation	Packard, M., Koo, E.S., Gorczyca, M., Sharpe, J., Cumberledge, S., Budnik, V. (2002). The Drosophila Wnt, wingless, provides an essential signal for pre- and postsynaptic differentiation. Cell 111(3): 319--330. (Export to RIS)
FlyBase ID	FBrf0151817
Publication Type	Research paper
PubMed ID	12419243
PubMed Abstract	At vertebrate neuromuscular junctions (NMJs), Agrin plays pivotal roles in synapse development, but molecules that activate synapse formation at central synapses are largely unknown. Members of the Wnt family are well established as morphogens, yet recently they have also been implicated in synapse maturation. Here we demonstrate that the Drosophila Wnt, Wingless (Wg), is essential for synapse development. We show that Wg and its receptor are expressed at glutamatergic NMJs, and that Wg is secreted by synaptic boutons. Loss of Wg leads to dramatic reductions in target-dependent synapse formation, and new boutons either fail to develop active zones and postsynaptic specializations or these are strikingly aberrant. We suggest that Wg signals the coordinated development of pre- and postsynaptic compartments.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (14)
	Ecol\lacZ^wg-17en40cP1 fz2^{ECD.GPI.Scer\UAS.T:Hsap\MYC} fz2^Scer\UAS.cCa por^G18 Scer\GAL4^BG487 Scer\GAL4^C57 Scer\GAL4^C164 Scer\GAL4^futsch-C380 Scer\GAL4^wg-Gal4 shi¹ shi^{K44A.Scer\UAS} wg^l-12 wg^{Scer\UAS.C.T:Avic\GFP} wg^{Scer\UAS.cHa.T:Ivir\HA1}
Constructs (5)
	P{UAS-fz2.C} P{UAS-fz2(ECD)-GPI} P{UAS-shi.K44A} P{UAS-wg.H.T:HA1} P{UAS-Wg-GFP}
Genes (13)
	arm dlg1 Ecol\lacZ futsch fz2 GluRIIA por Scer\GAL4 shi T:Avic\GFP T:Hsap\MYC T:Ivir\HA1 wg
Insertions (6)
	P{en1}wg^17en40cP1 P{GAL4}BG487 P{GAL4}C380 P{GawB}C57 P{GawB}C164 P{GawB}wg^Gal4