Reference Report

Reference
Citation	Adachi-Yamada, T., O'Connor, M.B. (2002). Morphogenetic apoptosis: a mechanism for correcting discontinuities in morphogen gradients. Dev. Biol. 251(1): 74--90. (Export to RIS)
FlyBase ID	FBrf0151891
Publication Type	Research paper
PubMed ID	12413899
PubMed Abstract	Smooth gradients of the morphogens Hh, Dpp, and Wg are required for proper development of Drosophila imaginal discs. Here, it is reported that, when a discontinuity is generated between two adjacent cells in the reception of either the Dpp or Wg signal, then cells on either side of the discontinuity boundary undergo apoptosis by activating the c-Jun N-terminal Kinase (JNK) pathway. Furthermore, in the medial region of the wing imaginal disc, the JNK pathway is also activated if cells do not receive the proper levels of Dpp and Hh signals. These observations suggest that cells within a developing field have the ability to access their spatial positions by comparing the level of morphogen signal they receive with that of their neighbors. This phenomenon is likely related to the process of cell competition, and we suggest that it is an evolutionarily important mechanism that helps prevent abnormal tissue specification and growth during development.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Aberrations (1)
	In(1)omb^H31
Alleles (25)
	arm^{S10.Scer\UAS.T:Hsap\MYC} Avic\GFP^Scer\UAS.cUa bi^omb-1 brk^Scer\UAS.cJa Dad^Scer\UAS.cTa dpp^Scer\UAS.cHa Ecol\lacZ^bi-Pol-1 Ecol\lacZ^brk-38-20 Ecol\lacZ^fz3-J29 Ecol\lacZ^puc-E69 Ecol\lacZ^salm-03602 fu¹ hep¹ hep^r75 pan^ΔN.Scer\UAS puc^E69 salm^Scer\UAS.cBa Scer\GAL4^Act5C.PI Scer\GAL4^ap-md544 Scer\GAL4^dpp.blk1 Scer\GAL4^{Scer\FRT.Act5C} tkv⁴ tkv⁴²⁷ tkv^CA.Scer\UAS vg^Scer\UAS.cKa
Constructs (12)
	P{Act5C-GAL4} P{AyGAL4} P{GAL4-dpp.blk1} P{UAS-arm.S10} P{UAS-brk.J} P{UAS-Dad.T} P{UAS-dpp.H} P{UAS-GFP.U} P{UAS-pan.dTCFΔN} P{UAS-salm.B} P{UAS-tkv.CA} P{UAS-vg.K}
Genes (20)
	arm Avic\GFP bi brk bsk Dad dpp Ecol\lacZ fu fz3 hep His3 Mad pan puc salm Scer\GAL4 T:Hsap\MYC tkv vg
Insertions (7)
	P{A92}puc^E69 P{GawB}ap^md544 P{lacW}bi^Pol-1 P{lacZ}brk^38-20 P{lacZ}fz3^J29 P{PZ}salm⁰³⁶⁰² P{SDFL}hep¹