Reference Report

Reference
Citation	Sato, M., Kornberg, T.B. (2002). FGF is an essential mitogen and chemoattractant for the air sacs of the Drosophila tracheal system. Dev. Cell 3(2): 195--207. (Export to RIS)
FlyBase ID	FBrf0151893
Publication Type	Research paper
PubMed ID	12194851
PubMed Abstract	The Drosophila adult has a complex tracheal system that forms during the pupal period. We have studied the derivation of part of this system, the air sacs of the dorsal thorax. During the third larval instar, air sac precursor cells bud from a tracheal branch in response to FGF, and then they proliferate and migrate to the adepithelial layer of the wing imaginal disc. In addition, FGF induces these air sac precursors to extend cytoneme-like filopodia to FGF-expressing cells. These findings provide evidence that FGF is a mitogen in Drosophila, correlate growth factor signaling with filopodial contact between signaling and responding cells, and suggest that FGF can act on differentiated tracheal cells to induce a novel behavior and role.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Alleles (28)
	Act5C^{Scer\UAS.T:Avic\GFP} Avic\GFP^{S65T.Scer\UAS} Avic\GFP^{Scer\UAS.S65A.V68L.S72A.T:Btau\MAPT} Avic\GFP^{Scer\UAS.T:Hsap\Myr2} Avic\GFP^{Ubi-p63E.T:Ecol\lacZ,T:Zzzz\nls1} bnl⁰⁰⁸⁵⁷ bnl^hs.PS bnl^{Scer\FRT.Disc\RFP-DsRed2.y.αTub84B} bnl^Scer\UAS.cSa bnl^αTub84B.PS btl^DN.Scer\UAS btl^{hs.T:λ\cI-DD} btl^KR.hs btl^{Scer\UAS.T:Avic\GFP-S65T} btl^{Scer\UAS.T:λ\cI-DD} Disc\RFP^{DsRed2.Scer\UAS} Disc\RFP^{DsRed2.αTub84B} Disc\RFP^DsRed2 Ecol\lacZ^bnl-06916 Ecol\lacZ^btl-H82 Ecol\lacZ^wg-en11 esg⁰⁵⁷³⁰ Scer\GAL4^btl.PS Scer\GAL4^dpp.X Scer\GAL4^{Scer\FRT.Act5C} T:Avic\GFP^S65T T:λ\cI^DD y^+t*
Constructs (18)
	P{AyGAL4} P{DN-R1} P{dpp-GAL4.X} P{GAL4-btl.S} P{hs-bnl.S} P{hs-btl^K->R} P{hs-λbtl} P{UAS-Act5C.T:GFP} P{UAS-bnl.S} P{UAS-btl::GFP-S65T} P{UAS-btl.λ} P{UAS-Disc\RFP.DsRed2} P{UAS-gapGFP} P{UAS-GFP.S65T} P{UAS-tauGFP} P{Ubi-GFP.nls} P{αTub84B(FRT.Disc\RFP^DsRed2.y⁺)bnl} P{αTub84B(-FRT)bnl}
Genes (20)
	Act5C Avic\GFP bnl btl Disc\RFP Ecol\lacZ esg htl rl Scer\GAL4 stumps T:Avic\GFP T:Btau\MAPT T:Ecol\lacZ T:Hsap\Myr2 T:Zzzz\nls1 T:λ\cI trh twi y
Insertions (3)
	P{en1}wg^en11 P{lwB}H82 P{PZ}bnl⁰⁶⁹¹⁶
Transcripts (1)
	Ecol\lacZ^btl-H82RA