Reference Report

Reference
Citation	Dubruille, R., Laurencon, A., Vandaele, C., Shishido, E., Coulon-Bublex, M., Swoboda, P., Couble, P., Kernan, M., Durand, B. (2002). Drosophila Regulatory factor X is necessary for ciliated sensory neuron differentiation. Development 129(23): 5487--5498. (Export to RIS)
FlyBase ID	FBrf0151940
Publication Type	Research paper
PubMed ID	12403718
PubMed Abstract	Ciliated neurons play an important role in sensory perception in many animals. Modified cilia at dendrite endings serve as sites of sensory signal capture and transduction. We describe Drosophila mutations that affect the transcription factor RFX and genetic rescue experiments that demonstrate its central role in sensory cilium differentiation. Rfx mutant flies show defects in chemosensory and mechanosensory behaviors but have normal phototaxis, consistent with Rfx expression in ciliated sensory neurons and neuronal precursors but not in photoreceptors. The mutant behavioral phenotypes are correlated with abnormal function and structure of neuronal cilia, as shown by the loss of sensory transduction and by defects in ciliary morphology and ultrastructure. These results identify Rfx as an essential regulator of ciliated sensory neuron differentiation in Drosophila.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (3)
	Df(3R)hth Df(3R)Rfx⁴⁹ Df(3R)S143702
Alleles (16)
	jumu^06142a jumu⁰⁶⁴³⁹ jumu^EP359 jumu^S143702 l(3)06142b^06142b l(3)A143.1F3^A143.1F3 Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Rfx⁴⁹ Rfx²⁵³ Rfx^Scer\UAS.cDa Scer\GAL4^elav-C155 Scer\GAL4^sca-109-68 stich1^D233 stich1^EP359 stich1^S143702 w^+mC
Constructs (2)
	P{UAS-mCD8::GFP.L} P{UAS-Rfx.D}
Genes (10)
	futsch jumu l(3)06142b l(3)A143.1F3 Mmus\Cd8a Rfx Scer\GAL4 stich1 T:Avic\GFP w
Insertions (9)
	P{?lArB}Rfx⁴⁹ P{EP}stich1^EP359 P{GawB}elav^C155 P{GawB}sca^109-68 P{lacW}stich1^S143702 P{lArB}l(3)A143.1F3^A143.1F3 P{PZ}jumu^06142a P{PZ}jumu⁰⁶⁴³⁹ P{UAS-mCD8::GFP.L}Ptp4E^LL4