Reference Report

Reference
Citation	Boll, W., Noll, M. (2002). The Drosophila Pox neuro gene: control of male courtship behavior and fertility as revealed by a complete dissection of all enhancers. Development 129(24): 5667--5681. (Export to RIS)
FlyBase ID	FBrf0151944
Publication Type	Research paper
PubMed ID	12421707
PubMed Abstract	We have dissected the entire cis-regulatory region of the Drosophila Pox neuro gene with regard to its enhancers, and have analyzed their functions by the selective addition to Pox neuro null mutant flies of one or several functions, each regulated by a complete or partial enhancer. We have identified at least 15 enhancers with an astounding complexity in arrangement and substructure that regulate Pox neuro functions required for the development of the peripheral and central nervous system and of most appendages. Many of these functions are essential for normal male courtship behavior and fertility. Two enhancers regulate the development of the penis, claspers and posterior lobes of male genitalia. Three enhancers, two of which overlap, control the development of chemosensory bristles in the labellum, legs and wings, some or all of which are required for the transmission of gustatory signals elicited by female pheromones. An additional enhancer regulates in the developing brain the connectivity of two specific neuronal clusters entrusted with processing olfactory pheromone signals from the antennal nerve. Finally, functions crucial for the ability of the male to copulate depend on an enhancer that activates Pox neuro expression in the embryonic ventral cord. In addition to these male courtship and fertility functions of Pox neuro, we have identified enhancers that regulate: (1) proper segmentation of tarsal segments in the leg disc and in homologous segments of the antennal disc; and (2) proper development of the wing hinge and hence the ability of the fly to fly.
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (2)
	Df(2R)Poxn^ΔM22-B5 Df(2R)WMG
Alleles (32)
	Avic\GFP^Scer\UAS.cUa CG8249^+tResdistal Poxn^BaK Poxn^BasiK Poxn^BsK Poxn^C1 Poxn^E77 Poxn^EvK Poxn^Full Poxn^L1 Poxn^P2 Poxn^PK Poxn^SaK Poxn^ScK Poxn^SuperA Poxn^XK Poxn^ΔBH Poxn^ΔKBs Poxn^ΔKX Poxn^ΔM22-B5 Poxn^ΔSH Poxn^ΔXBs Poxn^ΔXP Scer\GAL4^Poxn.6 Scer\GAL4^Poxn.9 Scer\GAL4^Poxn.13 Scer\GAL4^Poxn.14 Scer\GAL4^Poxn.581 Scer\GAL4^Poxn.BasiK tun^+tResdistal tun^M22 w^+mW.hs
Constructs (28)
	P{Poxn.BaK} P{Poxn.BasiK} P{Poxn.BsK} P{Poxn.C1} P{Poxn.E77} P{Poxn.EvK} P{Poxn.Full} P{Poxn.L1} P{Poxn.P2} P{Poxn.PK} P{Poxn.SaK} P{Poxn.ScK} P{Poxn.SuperA} P{Poxn.XK} P{Poxn.ΔBH} P{Poxn.ΔKBs} P{Poxn.ΔKX} P{Poxn.ΔSH} P{Poxn.ΔXBs} P{Poxn.ΔXP} P{Poxn-GAL4.6} P{Poxn-GAL4.9} P{Poxn-GAL4.13} P{Poxn-GAL4.14} P{Poxn-GAL4.581} P{Poxn-GAL4.BasiK} P{Resdistal} P{UAS-GFP.U}
Genes (6)
	Avic\GFP CG8249 Poxn Scer\GAL4 tun w
Insertions (30)
	P{lacW}tun^M22 P{Poxn.BaK}19 P{Poxn.BasiK}109 P{Poxn.BsK}2 P{Poxn.C1}1-86 P{Poxn.E77}19 P{Poxn.EvK}12 P{Poxn.Full}1 P{Poxn.L1}16 P{Poxn.P2}2-67 P{Poxn.PK}6 P{Poxn.PK}86 P{Poxn.SaK}64 P{Poxn.ScK}10 P{Poxn.SuperA}207-2 P{Poxn.SuperA}243 P{Poxn.XK}39 P{Poxn.ΔBH}1 P{Poxn.ΔKBs}10 P{Poxn.ΔKX}2a P{Poxn.ΔSH}8 P{Poxn.ΔXBs}6 P{Poxn.ΔXP}1 P{Poxn-GAL4.6}23 P{Poxn-GAL4.9}6 P{Poxn-GAL4.13}1 P{Poxn-GAL4.14}1-7 P{Poxn-GAL4.581}32 P{Poxn-GAL4.BasiK}5 P{Resdistal}2
Sequence features (9)
	Poxn_1 Poxn_2 Poxn_3 Poxn_4 Poxn_5 Poxn_6 Poxn_7 Poxn_8 Poxn_9