Reference Report

Reference
Citation	Caudy, A.A., Myers, M., Hannon, G.J., Hammond, S.M. (2002). Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev. 16(19): 2491--2496. (Export to RIS)
FlyBase ID	FBrf0152005
Publication Type	Research paper
PubMed ID	12368260
PubMed Abstract	RNA interference (RNAi) is a flexible gene silencing mechanism that responds to double-stranded RNA by suppressing homologous genes. Here, we report the characterization of RNAi effector complexes (RISCs) that contain small interfering RNAs and microRNAs (miRNAs). We identify two putative RNA-binding proteins, the Drosophila homolog of the fragile X mental retardation protein (FMRP), dFXR, and VIG (Vasa intronic gene), through their association with RISC. FMRP, the product of the human fragile X locus, regulates the expression of numerous mRNAs via an unknown mechanism. The possibility that dFXR, and potentially FMRP, use, at least in part, an RNAi-related mechanism for target recognition suggests a potentially important link between RNAi and human disease.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Alleles (12)
	AGO1^dsRNA.cCa AGO1^{MtnA.T:Uuuu\T7} AGO2^dsRNA.cCa Avic\GFP^dsRNA Fmr1^dsRNA.cCa Fmr1^{I307N.MtnA.T:Uuuu\T7} Fmr1^{MtnA.T:Uuuu\T7} Fmr1^{MtnA.T:Zzzz\FLAG} Ppyr\LUC^dsRNA.cBa vig^dsRNA.cCa vig^{MtnA.T:Uuuu\T7} vig^{MtnA.T:Zzzz\His6}
Genes (12)
	AGO1 AGO2 Avic\GFP Fmr1 mir-2b-1 mir-2b-2 mir-13a Ppyr\LUC T:Uuuu\T7 T:Zzzz\FLAG T:Zzzz\His6 vig