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Reference
Citation
Caudy, A.A., Myers, M., Hannon, G.J., Hammond, S.M. (2002). Fragile X-related protein and VIG associate with the RNA interference machinery.  Genes Dev. 16(19): 2491--2496.
FlyBase ID
FBrf0152005
Publication Type
Research paper
Abstract

RNA interference (RNAi) is a flexible gene silencing mechanism that responds to double-stranded RNA by suppressing homologous genes. Here, we report the characterization of RNAi effector complexes (RISCs) that contain small interfering RNAs and microRNAs (miRNAs). We identify two putative RNA-binding proteins, the Drosophila homolog of the fragile X mental retardation protein (FMRP), dFXR, and VIG (Vasa intronic gene), through their association with RISC. FMRP, the product of the human fragile X locus, regulates the expression of numerous mRNAs via an unknown mechanism. The possibility that dFXR, and potentially FMRP, use, at least in part, an RNAi-related mechanism for target recognition suggests a potentially important link between RNAi and human disease.

PubMed ID
PubMed Central ID
PMC187452 (PMC) (EuropePMC)
Related Publication(s)
Note

A new regulatory pathway for fragile X syndrome?
Hansen and Laird, 2002, Nat. Med. 8(11): 1204--1205 [FBrf0156005]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference
    Genes (9)
    Physical Interactions (5)
    Cell Lines (1)