Reference Report

Reference
Citation	Maurange, C., Paro, R. (2002). A cellular memory module conveys epigenetic inheritance of hedgehog expression during Drosophila wing imaginal disc development. Genes Dev. 16(20): 2672--2683. (Export to RIS)
FlyBase ID	FBrf0152011
Publication Type	Research paper
PubMed ID	12381666
PubMed Abstract	In Drosophila, the Trithorax-group (trxG) and Polycomb-group (PcG) proteins interact with chromosomal elements, termed Cellular Memory Modules (CMMs). By modifying chromatin, this ensures a stable heritable maintenance of the transcriptional state of developmental regulators, like the homeotic genes, that is defined embryonically. We asked whether such CMMs could also control expression of genes involved in patterning imaginal discs during larval development. Our results demonstrate that expression of the hedgehog gene, once activated, is maintained by a CMM. In addition, our experiments indicate that the switching of such CMMs to an active state during larval stages, in contrast to embryonic stages, may require specific trans-activators. Our results suggest that the patterning of cells in particular developmental fields in the imaginal discs does not only rely on external cues from morphogens, but also depends on the previous history of the cells, as the control by CMMs ensures a preformatted gene expression pattern.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Aberrations (1)
	In(2LR)O
Alleles (16)
	brm² Ecol\lacZ^{Abd-B.5F24.Scer\UAS} Ecol\lacZ^{hh-CMM.Scer\UAS} Ecol\lacZ^hh-P30 en^Scer\UAS.cGa hh^EP3521 hh^Scer\UAS.cIa hh-CMM^3.4 Pc³ ph-p⁴⁰⁹ Scer\GAL4^hs.PB Scer\GAL4^vg.PM trx^E2 w^+mC w^hh-CMM.3.4 w^mC.mut
Balancers (2)
	CyO CyO-P{GAL4-Hsp70.PB.w^mC.mut}MP
Constructs (7)
	P{GAL4-Hsp70.PB.w^mC.mut} P{GAL4-Hsp70.PB} P{GAL4-vg.M} P{UAS-en.G} P{UAS-hh.I} P{UAS-lacZ.Abd-B.5F24} P{UAS-lacZ.hh-CMM}
Genes (12)
	brm ci Ecol\lacZ en hh hh-CMM Pc ph-p Scer\GAL4 Trl trx w
Insertions (2)
	P{GAL4-Hsp70.PB.w^mC.mut}MP P{PZ}hh^P30