Reference Report

Reference
Citation	Hipfner, D.R., Weigmann, K., Cohen, S.M. (2002). The bantam gene regulates Drosophila growth. Genetics 161(4): 1527--1537. (Export to RIS)
FlyBase ID	FBrf0152024
Publication Type	Research paper
PubMed ID	12196398
PubMed Abstract	We report here the consequences of mutations of a novel locus, named bantam, whose product is involved in the regulation of growth in Drosophila. bantam mutant animals are smaller than wild type, due to a reduction in cell number but not cell size, and do not have significant disruptions in patterning. Conversely, overexpression of the bantam product using the EP element EP(3)3622 causes overgrowth of wing and eye tissue. Overexpression in clones of cells results in an increased rate of cell proliferation and a matched increase in cellular growth rate, such that the resulting tissue is composed of more cells of a size comparable to wild type. These effects are strikingly similar to those associated with alterations in the activity of the cyclinD-cdk4 complex. However, epistasis and genetic interaction analyses indicate that bantam and cyclinD-cdk4 operate independently. Thus, the bantam locus represents a novel regulator of tissue growth.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (2)
	Df(3L)Ar11 Df(3L)ban^Δ1
Alleles (20)
	Avic\GFP^{E.Scer\UAS.cSa} Avic\GFP^{S65T.Scer\UAS.T:SV40\nls2} ban^EP3208 ban^EP3622 ban^EPg30491 ban^L1170a Cdk4³ Cdk4^Scer\UAS.cMa CR43334^EPg35007 CycD^Scer\UAS.cMa EP3219^EP3219 ex^Scer\UAS.cBa l(3)L1170b^L1170b Pi3K92E^{Scer\UAS.T:Hsap\MYC} Scer\GAL4^Act5C.PP Scer\GAL4^Bx-MS1096 Scer\GAL4^en-e16E Scer\GAL4^GMR.PF Scer\GAL4^hs.2sev Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C}
Constructs (10)
	P{ex} P{GAL4-Act5C(FRT.CD2).P} P{GAL4-Act5C(-FRT).P} P{GAL4-Hsp70.sev} P{GAL4-ninaE.GMR} P{UAS-Cdk4.M} P{UAS-CycD.M} P{UAS-EGFP.S} P{UAS-GFP^S65T.nls} P{WT-Dp110}
Genes (22)
	Avic\GFP ban Cdk4 CG3402 CG13893 CG17181 CR43334 CycD EP3219 ex Gale l(3)L1170b MED14 MED30 Pi3K92E RabX6 Reg-2 Rev1 Scer\GAL4 Sfp33A4 T:Hsap\MYC T:SV40\nls2
Insertions (10)
	P{en2.4-GAL4}e16E P{EP}ban^EP3208 P{EP}ban^EP3622a P{EP}ban^EP3622b P{EP}EP3219^EP3219 P{EPg}ban^EPg30491a P{EPg}ban^EPg30491b P{EPg}CR43334^EPg35007 P{GawB}Bx^MS1096 P{lacW}ban^L1170a