Reference Report

Reference
Citation	Ma, J., Katz, E., Belote, J.M. (2002). Expression of proteasome subunit isoforms during spermatogenesis in Drosophila melanogaster. Insect Mol. Biol. 11(6): 627--639. (Export to RIS)
FlyBase ID	FBrf0152082
Publication Type	Research paper
PubMed ID	12421421
PubMed Abstract	In this study, we sought to identify and characterize all the proteasome genes of Drosophila melanogaster. Earlier work led to the identification of two genes encoding alpha4-type 20S proteasome subunit isoforms that are expressed exclusively in the male germline. Here we extend these results and show that six of the 20S proteasome subunits, and four of the 19S regulatory cap subunits, have gene duplications encoding male-specific isoforms. More detailed analyses of two of these male-specific subunits (Prosalpha3T and Prosalpha6T), using GFP-tagged reporter transgenes, revealed that they are predominantly localized to the nucleus at later stages of spermatogenesis and are present there in mature, motile sperm. These results suggest a possible role of a 'spermatogenesis-specific' proteasome in sperm differentiation and/or function.
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Language of Publication	English
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Parent Publication
Publication Type	Compendium
Abbreviation	Insect Mol. Biol.
Title	Insect Molecular Biology
Publication Year	1992-
ISBN/ISSN	0307-6975
Data from Reference
Alleles (5)
	Prosα3^{T:Avic\GFP-EGFP} Prosα3T^{T:Avic\GFP-EGFP} Prosα6T^{T:Avic\GFP-EGFP} T:Avic\GFP^EGFP w^+mW.hs
Constructs (3)
	P{Prosα3-EGFP.M} P{Prosα3T-EGFP.M} P{Prosα6T-EGFP.M}
Genes (45)
	Prosα1 Prosα2 Prosα3 Prosα3T Prosα4 Prosα4T1 Prosα4T2 Prosα5 Prosα6 Prosα6T Prosα7 Prosβ1 Prosβ2 Prosβ2R1 Prosβ2R2 Prosβ3 Prosβ4 Prosβ4R1 Prosβ4R2 Prosβ5 Prosβ5R1 Prosβ6 Prosβ7 Rpn1 Rpn2 Rpn3 Rpn5 Rpn6 Rpn7 Rpn8 Rpn9 Rpn10 Rpn11 Rpn12 Rpn12R Rpt1 Rpt2 Rpt3 Rpt3R Rpt4 Rpt4R Rpt5 Rpt6 Rpt6R w
Polypeptides (3)
	Pros29^{T:Avic\GFP-EGFP}PA Prosα3T^{T:Avic\GFP-EGFP}PA Prosα6T^{T:Avic\GFP-EGFP}PA