Reference Report

Reference
Citation	Held, L.I. (2002). Bristles induce bracts via the EGFR pathway on Drosophila legs. Mech. Dev. 117(1-2): 225--234. (Export to RIS)
FlyBase ID	FBrf0152194
Publication Type	Research paper
PubMed ID	12204262
PubMed Abstract	A long-standing mystery in Drosophila has been: how do certain bristles induce adjacent cells to make bracts (a type of thick hair) on their proximal side? The apparent answer, based on loss- and gain-of-function studies, is that they emit a signal that neighbors then transduce via the epidermal growth factor receptor pathway. Suppressing this pathway removes bracts, while hyperactivating it evokes bracts indiscriminately on distal leg segments. Misexpression of the diffusible ligand Spitz (but not its membrane-bound precursor) elicits extra bracts at normal sites. What remains unclear is how a secreted signal can have effects in one specific direction.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Aberrations (1)
	Df(2L)ast4
Alleles (16)
	aos^Scer\UAS.cHa Avic\GFP^{Scer\UAS.T:SV40\nls2} btl::Egfr^{Scer\UAS.T:λ\cI-DD} Egfr^DN.Scer\UAS Egfr^f24 Egfr^Scer\UAS.cBa Egfr^tsla Ras85D^e1B Ras85D^hs.M11.2 S⁰⁵⁶⁷¹ Scer\GAL4^Dll-md23 Scer\GAL4^sca-537.4 sev¹⁴ spi^s.Scer\UAS spi^Scer\UAS.cSa T:λ\cI^DD
Constructs (8)
	P{hs-Ras1.M11.2} P{UAS-Egfr.B} P{UAS-Egfr.DN} P{UAS-Egfr.λtop} P{UAS-GFP.nls} P{UAS-gil.H} P{UAS-spi.m} P{UAS-spi.s}
Genes (11)
	aos Avic\GFP btl::Egfr Egfr Ras85D S Scer\GAL4 sev spi T:SV40\nls2 T:λ\cI
Insertions (3)
	P{GawB}Dll^md23 P{GawB}sca^537.4 P{PZ}S⁰⁵⁶⁷¹