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Citation
O'Hare, K., Chadwick, B.P., Constantinou, A., Davis, A.J., Mitchelson, A., Tudor, M. (2002). A 5.9-kb tandem repeat at the euchromatin-heterochromatin boundary of the X chromosome of Drosophila melanogaster.  Mol. Genet. Genomics 267(5): 647--655.
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FBrf0152222
Publication Type
Research paper
Abstract

We present an analysis of a chromosomal walk in the region of the euchromatin-heterochromatin transition at the base of the X chromosome of Drosophila melanogaster. This region is difficult to analyse because of the presence of repeated sequences, and we have used cosmids to walk from the last euchromatic gene, suppressor of forked, towards the pericentric heterochromatin. The proximal 30-kb sequence we have isolated consists of repetitive DNA, including four tandem copies of a 5.9-kb sequence. This tandem repeat is itself a mosaic of other, mostly repeated, sequences, including part of a retrotransposon without long terminal repeats, a simple-sequence region of TAA repeats and part of a retrotransposon with long terminal repeats that has not been previously described. Although sequences homologous to these components are found elsewhere in the genome, this arrangement of repeated sequences is only found at the base of the X chromosome. It is conserved in D. melanogaster strains of different geographic origin, but is not conserved in even closely related species.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Mol. Genet. Genomics
    Title
    Molecular Genetics and Genomics
    Publication Year
    2001-
    ISBN/ISSN
    1617-4615 1617-4623
    Data From Reference
    Aberrations (7)
    Alleles (1)
    Genes (10)
    Natural transposons (2)
    Transgenic Constructs (1)