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Reference Report
| Reference | |||
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| Citation | Hardie, R.C., Martin, F., Cochrane, G.W., Juusola, M., Georgiev, P., Raghu, P. (2002). Molecular basis of amplification in Drosophila phototransduction. Roles for g protein, phospholipase C, and diacylglycerol kinase. Neuron 36(4): 689--701. (Export to RIS) | ||
| FlyBase ID | FBrf0152274 | ||
| Publication Type | Research paper | ||
| PubMed ID | 12441057 | ||
| PubMed Abstract | In Drosophila photoreceptors, the amplification responsible for generating quantum bumps in response to photoisomerization of single rhodopsin molecules has been thought to be mediated downstream of phospholipase C (PLC), since bump amplitudes were reportedly unaffected in mutants with greatly reduced levels of either G protein or PLC. We now find that quantum bumps in such mutants are reduced approximately 3- to 5-fold but are restored to near wild-type values by mutations in the rdgA gene encoding diacylglycerol kinase (DGK) and also by depleting intracellular ATP. The results demonstrate that amplification requires activation of multiple G protein and PLC molecules, identify DGK as a key enzyme regulating amplification, and implicate diacylglycerol as a messenger of excitation in Drosophila phototransduction. | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Neuron | ||
| Title | Neuron | ||
| Publication Year | 1988- | ||
| ISBN/ISSN | 0896-6273 | ||
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Data from Reference
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| Alleles (19)
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| Constructs (4)
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| Genes (8)
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