Reference Report

Reference
Citation	Takehana, A., Katsuyama, T., Yano, T., Oshima, Y., Takada, H., Aigaki, T., Kurata, S. (2002). Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae. Proc. Natl. Acad. Sci. U.S.A. 99(21): 13705--13710. (Export to RIS)
FlyBase ID	FBrf0152317
Publication Type	Research paper
PubMed ID	12359879
PubMed Abstract	In Drosophila, microbial infection activates an antimicrobial defense system involving the activation of proteolytic cascades in the hemolymph and intracellular signaling pathways, the immune deficiency (imd) and Toll pathways, in immune-responsive tissues. The mechanisms for microbial recognition are largely unknown. We report that, in larvae, the imd-mediated antibacterial defense is activated by peptidoglycan-recognition protein (PGRP)-LE, a PGRP-family member in Drosophila. Consistent with this, PGRP-LE binds to the diaminopimelic acid-type peptidoglycan, a cell-wall component of the bacteria capable of activating the imd pathway, but not to the lysine-type peptidoglycan. Moreover, PGRP-LE activates the prophenoloxidase cascade, a proteolytic cascade in the hemolymph. Therefore, PGRP-LE acts as a pattern-recognition receptor to the diaminopimelic acid-type peptidoglycan and activates both the proteolytic cascade and intracellular signaling in Drosophila immunity.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Proc. Natl. Acad. Sci. U.S.A.
Title	Proceedings of the National Academy of Sciences of the United States of America
Publication Year	1915-
ISBN/ISSN	0027-8424
Data from Reference
Aberrations (1)
	Df(2L)J4b
Alleles (8)
	Avic\GFP^Drs.PF Ecol\lacZ^Dpt.PR imd¹ PGRP-LE^GS1068 PGRP-LE^{Scer\UAS.T:Zzzz\FLAG} Rel^E38 Scer\GAL4^c564 Scer\GAL4^hs.PB
Constructs (4)
	P{Dipt2.2-lacZ} P{Drs-GFP.JM608} P{GAL4-Hsp70.PB} P{UAS-PGRP-LE.FLAG}
Genes (13)
	AttA AttB AttC AttD Avic\GFP Dpt Drs Ecol\lacZ imd PGRP-LE Rel Scer\GAL4 T:Zzzz\FLAG
Insertions (2)
	P{GawB}c564 P{GSV1}PGRP-LE^GS1068