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Citation
Shaffer, C.D., Stephens, G.E., Thompson, B.A., Funches, L., Bernat, J.A., Craig, C.A., Elgin, S.C.R. (2002). Heterochromatin protein 2 (HP2), a partner of HP1 in Drosophila heterochromatin.  Proc. Natl. Acad. Sci. U.S.A. 99(22): 14332--14337.
FlyBase ID
FBrf0152321
Publication Type
Research paper
Abstract

Heterochromatin protein 1 (HP1), first discovered in Drosophila melanogaster, is a highly conserved chromosomal protein implicated in both heterochromatin formation and gene silencing. We report here characterization of an HP1-interacting protein, heterochromatin protein 2 (HP2), which codistributes with HP1 in the pericentric heterochromatin. HP2 is a large protein with two major isoforms of approximately 356 and 176 kDa. The smaller isoform is produced from an alternative splicing pattern in which two exons are skipped. Both isoforms contain the domain that interacts with HP1; the larger isoform contains two AT-hook motifs. Mutations recovered in HP2 act as dominant suppressors of position effect variegation, confirming a role in heterochromatin spreading and gene silencing.

PubMed ID
PubMed Central ID
PMC137884 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Proc. Natl. Acad. Sci. U.S.A.
    Title
    Proceedings of the National Academy of Sciences of the United States of America
    Publication Year
    1915-
    ISBN/ISSN
    0027-8424
    Data From Reference
    Aberrations (4)
    Alleles (7)
    Genes (12)
    Physical Interactions (4)
    Insertions (1)
    Transgenic Constructs (1)