Reference Report

Reference
Citation	Belgacem, Y.H., Martin, J.R. (2002). Neuroendocrine control of a sexually dimorphic behavior by a few neurons of the pars intercerebralis in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 99(23): 15154--15158. (Export to RIS)
FlyBase ID	FBrf0152325
Publication Type	Research paper
PubMed ID	12399547
PubMed Abstract	In Drosophila, locomotor activity is sexually dimorphic and the brain area controlling this dimorphism has been mapped. The neurons of the pars intercerebralis (PI) have been suggested to participate in such differences between males and females. However, the precise physical nature of the dimorphism, the identity of the PI neurons involved, and the nature of the neuronal signal coding the dimorphism remain unknown. In this study, we used a video-tracking paradigm to characterize further the pattern of locomotor activity in Drosophila. We show that the number of activity/inactivity periods (start/stop bouts) is also sexually dimorphic, and that it can be genetically feminized in males. Moreover, the transplantation of PI neurons from a female, or of feminized PI neurons from a donor male into a receiver wild-type male is sufficient to induce the feminization of locomotor behavior, confirming that this tiny cluster of approximately 10 neurons is directly responsible for the sexual dimorphism in locomotor activity. Finally, feeding males with fluvastatin, a juvenile hormone (JH) inhibitor, also led to start/stop feminization, and this effect is reversible by the simultaneous application of methoprene, a JH analog, suggesting the existence of a neuroendocrine control, by JH, of such behavioral dimorphism.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Proc. Natl. Acad. Sci. U.S.A.
Title	Proceedings of the National Academy of Sciences of the United States of America
Publication Year	1915-
ISBN/ISSN	0027-8424
Data from Reference
Alleles (10)
	Avic\GFP^Scer\UAS.cUa oc¹ Scer\GAL4^30Y Scer\GAL4^103Y Scer\GAL4^121Y Scer\GAL4^Aph-4-c232 Scer\GAL4^c35 Scer\GAL4^elav-C155 Scer\GAL4^pros-V1 tra^Scer\UAS.cFa
Constructs (2)
	P{UAS-GFP.U} P{UAS-tra.F}
Genes (4)
	Avic\GFP oc Scer\GAL4 tra
Insertions (7)
	P{GawB}30Y P{GawB}103Y P{GawB}121Y P{GawB}Aph-4^c232 P{GawB}c35 P{GawB}elav^C155 P{GawB}pros^V1
Transcripts (2)
	Scer\GAL4^103YRA Scer\GAL4^121YRA