Reference Report

Reference
Citation	Moore, A.W., Jan, L.Y., Jan, Y.N. (2002). hamlet, a binary genetic switch between single- and multiple- dendrite neuron morphology. Science 297(5585): 1355--1358. (Export to RIS)
FlyBase ID	FBrf0152335
Publication Type	Research paper
PubMed ID	12193790
PubMed Abstract	The dendritic morphology of neurons determines the number and type of inputs they receive. In the Drosophila peripheral nervous system (PNS), the external sensory (ES) neurons have a single nonbranched dendrite, whereas the lineally related multidendritic (MD) neurons have extensively branched dendritic arbors. We report that hamlet is a binary genetic switch between these contrasting morphological types. In hamlet mutants, ES neurons are converted to an MD fate, whereas ectopic hamlet expression in MD precursors results in transformation of MD neurons into ES neurons. Moreover, hamlet expression induced in MD neurons undergoing dendrite outgrowth drastically reduces arbor branching.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Science
Title	Science
Publication Year	1895-
ISBN/ISSN	0036-8075
Data from Reference
Aberrations (4)
	Df(2L)OD15 Df(2L)TW3 Df(2L)TW201 Df(2L)VA20
Alleles (10)
	Avic\GFP^{S65T.Scer\UAS} Ecol\lacZ^E7-2-36 ham¹ ham^dsRNA.cMa ham^Scer\UAS.cMa Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^109(2)80 Scer\GAL4^elav.PLu Scer\GAL4^pros.PMG w^+mC
Constructs (5)
	P{GAL4-elav.L} P{GAL4-pros.MG} P{UAS-GFP.S65T} P{UAS-ham.M} P{UAS-mCD8::GFP.L}
Genes (18)
	Avic\GFP ct Ecol\lacZ elav futsch ham hk l(2)36Fc l(2)36Fd l(2)36Fe l(2)37Ac Mmus\Cd8a msl-1 pros Scer\GAL4 T:Avic\GFP tup w
Insertions (2)
	P{GawB}109(2)80 P{lacW}E7-2-36