Reference Report

Reference
Citation	Stathopoulos, A., Van Drenth, M., Erives, A., Markstein, M., Levine, M. (2002). Whole-genome analysis of dorsal-ventral patterning in the Drosophila embryo. Cell 111(5): 687--701. (Export to RIS)
FlyBase ID	FBrf0155522
Publication Type	Research paper
PubMed ID	12464180
PubMed Abstract	The maternal Dorsal regulatory gradient initiates the differentiation of several tissues in the early Drosophila embryo. Whole-genome microarray assays identified as many as 40 new Dorsal target genes, which encode a broad spectrum of cell signaling proteins and transcription factors. Evidence is presented that a tissue-specific form of the NF-Y transcription complex is essential for the activation of gene expression in the mesoderm. Tissue-specific enhancers were identified for new Dorsal target genes, and bioinformatics methods identified conserved cis-regulatory elements for coordinately regulated genes that respond to similar thresholds of the Dorsal gradient. The new Dorsal target genes and enhancers represent one of the most extensive gene networks known for any developmental process.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (8)
	Ecol\lacZ^Ilp4.260 Ecol\lacZ^ths.510 Ecol\lacZ^vnd.1.7 Mes4^Kr.enh pip¹ pip² Tl⁸ Tl^r4
Constructs (4)
	P{Ilp4-lacZ.260} P{Kr-Mes4.S} P{ths-lacZ.510} P{vnd-lacZ.1.7}
Genes (90)
	Acp1 Act57B Ance Argk Asph brk BRWD3 C15 CG4500 CG4749 CG6180 CG9466 CG12011 CG12177 CG14036 CG14411 CG14688 CG15282 CG30020 CG34383 CG42669 CG43867 Chrac-16 Cyp310a1 DNaseII Doc1 Doc3 dpp Dscam Ecol\lacZ Ect3 Ect4 ed egr fog gcm hoip htl Ilp4 ind l(1)sc Lcp65Ag2 lea Letm1 loco magu Mbs Mdr49 Mef2 Meltrin Mes2 Mes4 NC2α NC2β Neu2 Nf-YA Nf-YB Nf-YC PGRP-SC2 Phk-3 Pif1A pip pnr ptc rho RhoL ry sca sim sna Socs36E sog SoxN stumps Sulf1 Taf5 ths tin Tl tld trh tup TwdlM TwdlN twi ush vnd wts zen zfh1
Sequence features (3)
	Ilp4_Mes3_early_embryonic_enhancer ths_Neu4_early_embryonic_enhancer vnd_early_embryonic_enhancer
Transcripts (3)
	Ecol\lacZ^Ilp4.260RA Ecol\lacZ^ths.510RA Ecol\lacZ^vnd.1.7RA