Reference Report

Reference
Citation	Komiyama, T., Johnson, W.A., Luo, L., Jefferis, G.S. (2003). From lineage to wiring specificity. POU domain transcription factors control precise connections of Drosophila olfactory projection neurons. Cell 112(2): 157--167. (Export to RIS)
FlyBase ID	FBrf0155593
Publication Type	Research paper
PubMed ID	12553905
PubMed Abstract	Axonal selection of synaptic partners is generally believed to determine wiring specificity in the nervous system. However, we have recently found evidence for specific dendritic targeting in the olfactory system of Drosophila: second order olfactory neurons (Projection Neurons) from the anterodorsal (adPN) and lateral (lPN) lineages send their dendrites to stereotypical, intercalating but non-overlapping glomeruli. Here we show that POU domain transcription factors, Acj6 and Drifter, are expressed in adPNs and lPNs respectively, and are required for their dendritic targeting. Moreover, misexpression of Acj6 in lPNs, or Drifter in adPNs, results in dendritic targeting to glomeruli normally reserved for the other PN lineage. Thus, Acj6 and Drifter translate PN lineage information into distinct dendritic targeting specificity. Acj6 also controls stereotypical axon terminal arborization of PNs in a central target, suggesting that the connectivity of PN axons and dendrites in different brain centers is coordinately regulated.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (7)
	acj6^1,4.Scer\UAS acj6⁶ Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^GH146 Scer\GAL80^αTub84B.PL vvl^dfr-B129 vvl^Scer\UAS.cCa
Constructs (4)
	P{tubP-GAL80} P{UAS-acj6.1,4} P{UAS-mCD8::GFP.L} P{UAS-vvl.C}
Genes (7)
	acj6 elav Mmus\Cd8a Scer\GAL4 Scer\GAL80 T:Avic\GFP vvl
Insertions (1)
	P{GawB}GH146