Reference Report

Reference
Citation	Zheng, X., Wang, J., Haerry, T.E., Wu, A.Y.H., Martin, J., O'Connor, M.B., Lee, C.H.J., Lee, T. (2003). TGF-beta signaling activates steroid hormone receptor expression during neuronal remodeling in the Drosophila brain. Cell 112(3): 303--315. (Export to RIS)
FlyBase ID	FBrf0155597
Publication Type	Research paper
PubMed ID	12581521
PubMed Abstract	Metamorphosis of the Drosophila brain involves pruning of many larval-specific dendrites and axons followed by outgrowth of adult-specific processes. From a genetic mosaic screen, we recovered two independent mutations that block neuronal remodeling in the mushroom bodies (MBs). These phenotypically indistinguishable mutations affect Baboon function, a Drosophila TGF-beta/activin type I receptor, and dSmad2, its downstream transcriptional effector. We also show that Punt and Wit, two type II receptors, act redundantly in this process. In addition, knocking out dActivin around the mid-third instar stage interferes with remodeling. Binding of the insect steroid hormone ecdysone to distinct ecdysone receptor isoforms induces different metamorphic responses in various larval tissues. Interestingly, expression of the ecdysone receptor B1 isoform (EcR-B1) is reduced in activin pathway mutants, and restoring EcR-B1 expression significantly rescues remodeling defects. We conclude that the Drosophila Activin signaling pathway mediates neuronal remodeling in part by regulating EcR-B1 expression.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (9)
	Df(1)C128 Df(1)Desi-S3 Df(1)GE202 Df(1)hl-a Df(1)RA2 Df(2R)G75 Df(2R)H3E1 Df(2R)Np1 Df(2R)Np4
Alleles (19)
	Actβ^CM.Scer\UAS Actβ^{dsRNA.HL.Scer\UAS} babo⁴ babo⁹ babo⁵² babo^Scer\UAS.cZa EcR^A.Scer\UAS EcR^B1.Scer\UAS EcR^B2.Scer\UAS put¹³⁵ put^Δ61 Scer\GAL4^arm.PS Scer\GAL4^ey-OK107 Scer\GAL4^hs.PB Scer\GAL4^Tab2-201Y Scer\GAL4^αTub84B.PL Smox^MB388 Smox^Scer\UAS.cZa wit^G15
Constructs (10)
	P{GAL4-arm.S} P{GAL4-Hsp70.PB} P{tubP-GAL4} P{UAS-activin-β.CM} P{UAS-activin-β.HL.dsRNA} P{UAS-babo.Z} P{UAS-dSmad2.Z} P{UAS-EcR.A} P{UAS-EcR.B1} P{UAS-EcR.B2}
Genes (24)
	Actβ babo EcR flz fs(1)h fs(1)M122 l(1)7Dc l(1)7Dd l(1)7De l(1)7Df l(1)7Dg l(1)7Dh l(1)7Di l(1)7Dj l(1)7Dk l(1)7Dl l(1)7Dm lin mys put Scer\GAL4 Smox sn wit
Insertions (3)
	P{?cp70ZT}babo⁵² P{GawB}ey^OK107 P{GawB}Tab2^201Y