Reference Report

Reference
Citation	Cai, Y., Yu, F., Lin, S., Chia, W., Yang, X. (2003). Apical complex genes control mitotic spindle geometry and relative size of daughter cells in Drosophila neuroblast and pI asymmetric divisions. Cell 112(1): 51--62. (Export to RIS)
FlyBase ID	FBrf0155600
Publication Type	Research paper
PubMed ID	12526793
PubMed Abstract	Drosophila neuroblast asymmetric divisions generate two daughters of unequal size and fate. A complex of apically localized molecules mediates basal localization of cell fate determinants and apicobasal orientation of the mitotic spindle, but how daughter cell size is controlled remains unclear. Here we show that mitotic spindle geometry and unequal daughter cell size are controlled by two parallel pathways (Bazooka/DaPKC and Pins/G alpha i) within the apical complex. While the localized activity of either pathway alone is sufficient to mediate the generation of an asymmetric mitotic spindle and unequal size neuroblast daughters, loss of both pathways results in symmetric divisions. In sensory organ precursors, Bazooka/DaPKC and Pins/G alpha i localize to opposite sides of the cortex and function in opposition to generate a symmetric spindle.
DOI
Related Publication(s)
Review	Little and large. Anonymous, 2003, Science 299(5606): 475 [FBrf0155377]
Personal communication to FlyBase	Queries for FlyBase Curation. Yang, 2003.2.27, Queries for FlyBase Curation. [FBrf0157193]
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Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (1)
	Df(2L)TE35BC-3
Alleles (21)
	aPKC^dsRNA.cCa baz⁴ baz^dsRNA.cCa esg^G66 Gαi^dsRNA.cCa Gαi^Scer\UAS.cCa Hsap\HIST2H2BE^{Scer\UAS.T:Avic\GFP-YFP} insc²² insc^Scer\UAS.cKa pon::raps^{c-pon.Scer\UAS} raps^{C.Hsp70Bb.T:Zzzz\FLAG,T:Zzzz\FLAG} raps^{C.Scer\UAS.T:Zzzz\FLAG,T:Zzzz\FLAG} raps^P62 raps^P89 raps^unspecified Scer\GAL4^hs.PB Scer\GAL4^neur-P72 Scer\GAL4^sca-P309 sna¹ T:Avic\GFP^YFP wor^dsRNA.cCa
Constructs (7)
	P{GAL4-Hsp70.PB} P{hs-raps.C} P{UAS-G-iα65A} P{UAS-H2B-T:Avic\GFP-YFP} P{UAS-insc.K} P{UAS-pon::raps.C-pon} P{UAS-raps.C}
Genes (20)
	aPKC baz cnn ct esg Gαi Gβ13F Hsap\HIST2H2BE insc Nrt numb pon pon::raps pros raps Scer\GAL4 sna T:Avic\GFP T:Zzzz\FLAG wor
Insertions (2)
	P{GAL4}neur^P72 P{GAL4}sca^P309