Home
Reference Report
| Reference | |||
|---|---|---|---|
| Citation | Vied, C., Halachmi, N., Salzberg, A., Horabin, J.I. (2003). Antizyme is a target of Sex-lethal in the Drosophila germline and appears to act downstream of Hedgehog to regulate Sex-lethal and Cyclin B. Dev. Biol. 253(2): 214--219. (Export to RIS) | ||
| FlyBase ID | FBrf0155664 | ||
| Publication Type | Research paper | ||
| PubMed ID | 12645926 | ||
| PubMed Abstract | The sex determination master switch, Sex-lethal, has been shown to regulate the mitosis of early germ cells in Drosophila melanogaster. Sex-lethal is an RNA binding protein that regulates splicing and translation of specific targets in the soma, but the germline targets are unknown. In an experiment aimed at identifying targets of Sex-lethal in early germ cells, the RNA encoded by gutfeeling, the Drosophila homolog of Ornithine Decarboxylase Antizyme, was isolated. gutfeeling interacts genetically with Sex-lethal. It is not only a target of Sex-lethal, but also appears to regulate the nuclear entry and overall levels of Sex-lethal in early germ cells. This regulation of Sex-lethal by gutfeeling appears to occur downstream of the Hedgehog signal. We also show that Hedgehog, Gutfeeling, and Sex-lethal function to regulate Cyclin B, providing a link between Sex-lethal and mitosis. | ||
| DOI | |||
| Related Publication(s) | |||
| Erratum | Corrigendum to “Antizyme is a target of Sex-lethal in the Drosophila germline and appears to act downstream of Hedgehog to
regulate Sex-lethal and Cyclin B” [Dev. Biol. 253 (2003) 214–229]. Vied et al., 2007, Dev. Biol. 302(2): 728 [FBrf0202141] |
||
Recent Updates
|
|||
| Description |
What does this section display?
This section contains items that were added to this record for each release.
It currently only tracks new links between this FlyBase report and other
FlyBase data classes (e.g. genes, references, stocks) or controlled
vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
|
||
| Update Feed |
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your
feed reader.
|
||
| FB2013_03 | |||
| FB2013_02 | |||
| All updates | Click here to see a list of all updates to this record from FB2010_08 and on. | ||
|
Associated Information
|
|||
| Comments | |||
| Associated Files | |||
|
Other Information
|
|||
| Secondary IDs | |||
| Language of Publication | English | ||
| Additional Languages of Abstract | |||
| Also Published As | |||
|
Parent Publication
|
|||
| Publication Type | Journal | ||
| Abbreviation | Dev. Biol. | ||
| Title | Developmental Biology | ||
| Publication Year | 1959- | ||
| ISBN/ISSN | 0012-1606 | ||
|
Data from Reference
|
|||
| Alleles (13)
|
|||
| Constructs (5)
|
|||
| Genes (9)
|
|||
| Insertions (1)
|
|||