Reference Report

Reference
Citation	Zraly, C.B., Marenda, D.R., Nanchal, R., Cavalli, G., Muchardt, C., Dingwall, A.K. (2003). SNR1 is an essential subunit in a subset of Drosophila Brm complexes, targeting specific functions during development. Dev. Biol. 253(2): 291--308. (Export to RIS)
FlyBase ID	FBrf0155665
Publication Type	Research paper
PubMed ID	12645932
PubMed Abstract	The snr1 gene of Drosophila melanogaster encodes a conserved component of the multiprotein Brahma (Brm) complex, a counterpart to the SWI/SNF complexes that participate in ATP-dependent chromatin remodeling. Loss-of-function and null mutations in the snr1 gene reveal its essential role in Drosophila development. We identified new mutant alleles and ectopically expressed deleted forms to dissect the specific functions of SNR1. Somatic and germ cell clone analyses confirmed its requirement in a continuous and widespread fashion for proper cell fate determination and oogenesis. Expression of SNR1 transgenes revealed unexpected roles in wing patterning, abdomen development, oogenesis, and sustained adult viability. A widespread distribution of SNR1 and BRM on the salivary gland polytene chromosomes showed that the Brm complex associated with many genes, but not always at transcribed loci, consistent with genetic data suggesting roles in both gene activation and repression. Despite essential Brm complex functions in leg development, genetic and protein localization studies revealed that snr1 was not required or expressed in all tissues dependent on Brm complex activities. Thus, SNR1 is essential for some, but not all Brm functions, and it likely serves as an optional subunit, directing Brm complex activity to specific gene loci or cellular processes.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Aberrations (3)
	Df(3R)SR29 Df(3R)SR71 In(1)w^m4h
Alleles (27)
	Antp^Ns brm² E(var)3-4^unspecified mor¹ osa² Scer\GAL4^69B Scer\GAL4^Act5C.PI Scer\GAL4^e22c Scer\GAL4^hs.PB Snr1^3.Scer\UAS Snr1^4.Scer\UAS Snr1⁰¹³¹⁹ Snr1^+t8.9 Snr1^{cdel.3.Scer\UAS} Snr1^E1 Snr1^E2 Snr1^E3 Snr1^E4 Snr1^hs.PZ Snr1^P1rev Snr1^R3 Snr1^Scer\UAS.cZa Snr1^SR21 Snr1^unspecified Su(var)205^unspecified trx^E2 w^+mC
Constructs (8)
	P{Act5C-GAL4} P{GAL4-Hsp70.PB} P{hs-Snr1.Z} P{Snr1^+t8.9} P{UAS-Snr1.1} P{UAS-Snr1.3} P{UAS-Snr1.4} P{UAS-snr1.cdel.3}
Genes (11)
	Antp brm E(var)3-4 mor osa RpII140 Scer\GAL4 Snr1 Su(var)205 trx w
Insertions (3)
	P{en2.4-GAL4}e22c P{GawB}69B P{PZ}Snr1⁰¹³¹⁹