Reference Report

Reference
Citation	Chou, Y.H., Chien, C.T. (2002). Scabrous controls ommatidial rotation in the Drosophila compound eye. Dev. Cell 3(6): 839--850. (Export to RIS)
FlyBase ID	FBrf0155677
Publication Type	Research paper
PubMed ID	12479809
PubMed Abstract	Establishment of planar polarity in the Drosophila compound eye requires precise 90 degrees rotation of the ommatidial clusters during development. We found that the morphogenetic furrow controls the stop of ommatidial rotation at 90 degrees by emitting signals to posterior ommatidial clusters. One such signal, Scabrous, is synthesized in the furrow cells and transported in vesicles to ommatidial row 6-8. Scabrous vesicles are transported through actin-based cellular extensions but not transcytosis. Scabrous functions nonautonomously to control the stop of ommatidial rotation by suppressing nemo activity in the second 45 degrees rotation. We propose that the morphogenetic furrow regulates precise ommatidial rotation by transporting Scabrous and perhaps other factors through actin-based cellular extensions.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Alleles (25)
	ato¹ Ecol\lacZ^HLHmδ.0.5 Ecol\lacZ^svp-AE127 hh^bar3 hh^Scer\UAS.cAa N^l1N-ts1 nmo^{c5-1.Scer\UAS} nmo^j147-1 nmo^P1 nmo^unspecified Rab5^{S43N.Scer\UAS} ro^DOM sca^73-1 sca^BP1 sca^BP2 sca^Scer\UAS.cEa sca^{Scer\UAS.T:Avic\GFP-EGFP} Scer\GAL4^Act5C.PI Scer\GAL4^GMR.PF Scer\GAL4^hs.2sev Scer\GAL4^{Scer\FRT.Act5C} shi^1.Scer\UAS smo³ T:Avic\GFP^EGFP tkv⁸
Constructs (10)
	P{Act5C-GAL4} P{AyGAL4} P{GAL4-Hsp70.sev} P{GAL4-ninaE.GMR} P{HLHmδ-lacZ.0.5} P{UAS-hh.A} P{UAS-Rab5.S43N} P{UAS-sca.E} P{UAS-sca-EGFP} P{UAS-shi^ts1.K}
Genes (16)
	ato B Ecol\lacZ elav hh N nmo Rab5 ro sca Scer\GAL4 shi smo T:Avic\GFP tkv wg
Insertions (2)
	P{GawB}sca^73-1 P{lwB}svp^AE127