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Reference
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| Citation |
Strutt, H., Strutt, D. (2002). Nonautonomous planar polarity patterning in Drosophila: dishevelled-independent functions of frizzled. Dev. Cell 3(6): 851--863. |
| FlyBase ID |
FBrf0155678 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
12479810 |
| PubMed Abstract |
The frizzled (fz) gene of Drosophila is required for planar polarity establishment in the adult cuticle, acting both cell
autonomously and nonautonomously. We demonstrate that these two activities of fz in planar polarity are temporally separable
in both the eye and wing. The nonautonomous function is dishevelled (dsh) independent, and its loss results in polarity phenotypes
that resemble those seen for mutations in dachsous (ds). Genetic interactions and epistasis analysis suggest that fz, ds,
and fat (ft) act together in the long-range propagation of polarity signals in the eye and wing. We also find evidence that
polarity information may be propagated by modulation of the binding affinities of the cadherins encoded by the ds and ft loci.
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| Biosis |
2003.82007 |
| Zoological record |
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Associated Information
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| Text of personal communication |
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Related Publications
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
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Published In
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| Abbreviation |
Dev. Cell |
| Title |
Developmental Cell |
| Authors |
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| Volume range |
1- |
| Year range |
2001- |
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| Publisher |
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| Place of publication |
Cambridge, MA |
| Language of publication |
English |
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Data from Reference
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| Aberrations (2)
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| Alleles (16)
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| Constructs (5)
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| Genes (5)
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