Reference Report

Reference
Citation	Munier, A.I., Doucet, D., Perrodou, E., Zachary, D., Meister, M., Hoffmann, J.A., Janeway, C.A., Lagueux, M. (2002). PVF2, a PDGF/VEGF-like growth factor, induces hemocyte proliferation in Drosophila larvae. EMBO Rep. 3(12): 1195--1200. (Export to RIS)
FlyBase ID	FBrf0155740
Publication Type	Research paper
PubMed ID	12446570
PubMed Abstract	Blood cells play a crucial role in both morphogenetic and immunological processes in Drosophila, yet the factors regulating their proliferation remain largely unknown. In order to address this question, we raised antibodies against a tumorous blood cell line and identified an antigenic determinant that marks the surface of prohemocytes and also circulating plasmatocytes in larvae. This antigen was identified as a Drosophila homolog of the mammalian receptor for platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF). The Drosophila receptor controls cell proliferation in vitro. By overexpressing in vivo one of its putative ligands, PVF2, we induced a dramatic increase in circulating hemocytes. These results identify the PDGF/VEGF receptor homolog and one of its ligands as important players in Drosophila hematopoiesis.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	EMBO Rep.
Title	EMBO Reports
Publication Year	2000-
ISBN/ISSN
Data from Reference
Alleles (11)
	hop^Tum Pvf1^EP1624 Pvf1^Scer\UAS.cMb Pvf2^c06947 Pvf2^d02444 Pvf2^Scer\UAS.cMa Pvr^c02195 Pvr^Scer\UAS.cMa Scer\GAL4^da.G32 Scer\GAL4^e33C w^+mC
Constructs (4)
	P{GAL4-da.G32} P{UAS-Pvf1.Mb} P{UAS-Pvf2.M} P{UAS-Pvr.M}
Genes (7)
	His3 hop Pvf1 Pvf2 Pvr Scer\GAL4 w
Insertions (5)
	P{en2.4-GAL4}e33C P{EP}Pvf1^EP1624 P{XP}Pvf2^d02444 PBac{PB}Pvf2^c06947 PBac{PB}Pvr^c02195
Natural transposons (1)
	P-element