Open Close
Reference
Citation
Kambris, Z., Bilak, H., D'Alessandro, R., Belvin, M., Imler, J.L., Capovilla, M. (2003). DmMyD88 controls dorsoventral patterning of the Drosophila embryo.  EMBO Rep. 4(1): 64--69.
FlyBase ID
FBrf0155743
Publication Type
Research paper
Abstract

MyD88 is an adapter protein in the signal transduction pathway mediated by interleukin-1 (IL-1) and Toll-like receptors. A Drosophila homologue of MyD88 (DmMyD88) was recently shown to be required for the Toll-mediated immune response. In Drosophila, the Toll pathway was originally characterized for its role in the dorsoventral patterning of the embryo. We found that, like Toll, DmMyD88 messenger RNA is maternally supplied to the embryo. Here we report the identification of a new mutant allele of DmMyD88, which generates a protein lacking the carboxy-terminal extension, normally located downstream of the Toll/IL-1 receptor domain. Homozygous mutant female flies lay dorsalized embryos that are rescued by expression of a transgenic DmMyD88 complementary DNA. The DmMyD88 mutation blocks the ventralizing activity of a gain-of-function Toll mutation. These results show that DmMyD88 encodes an essential component of the Toll pathway in dorsoventral pattern formation.

PubMed ID
PubMed Central ID
PMC1315814 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    EMBO Rep.
    Title
    EMBO Reports
    Publication Year
    2000-
    ISBN/ISSN
    1469-221X 1469-3178
    Data From Reference
    Aberrations (2)
    Alleles (6)
    Genes (6)
    Natural transposons (1)
    Insertions (2)
    Transgenic Constructs (3)