Reference Report

Reference
Citation	Stanewsky, R. (2003). Genetic analysis of the circadian system in Drosophila melanogaster and mammals. J. Neurobiol. 54(1): 111--147. (Export to RIS)
FlyBase ID	FBrf0155881
Publication Type	Review
PubMed ID	12486701
PubMed Abstract	The fruit fly, Drosophila melanogaster, has been a grateful object for circadian rhythm researchers over several decades. Behavioral, genetic, and molecular studies helped to reveal the genetic bases of circadian time keeping and rhythmic behaviors. Contrary, mammalian rhythm research until recently was mainly restricted to descriptive and physiologic approaches. As in many other areas of research, the surprising similarity of basic biologic principles between the little fly and our own species, boosted the progress of unraveling the genetic foundation of mammalian clock mechanisms. Once more, not only the basic mechanisms, but also the molecules involved in establishing our circadian system are taken or adapted from the fly. This review will try to give a comparative overview about the two systems, highlighting similarities as well as specifics of both insect and murine clocks.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	J. Neurobiol.
Title	Journal of Neurobiology
Publication Year	1969-
ISBN/ISSN	0022-3034
Data from Reference
Aberrations (1)
	Df(3R)Nf1^P1
Alleles (54)
	CkIIβ^And Clk^ar Clk^Jrk CrebB^S162 cry^b cyc⁰¹ cyc⁰² dco^ar dco^g dco^h dco^j3B9 dco^L dco^S dnc¹ dnc^ML lark^a Nf1^P2 numb¹ numb³ numb^nuts numb^SW Pdf⁰¹ per⁰¹ per⁰⁴ per^Clk per^L1 per^s per^SLIH per^T Pka-C1^B3 Pka-C1^B10 Pka-C1^MB581 Pka-C1^T4 Pka-C1^X4 Pka-R2^EP2162 sgg³² sgg^EP1576 sgg^M11 tim⁰¹ tim⁰³ tim⁰⁴ tim^L1 tim^L2 tim^L3 tim^L4 tim^rit tim^S1 tim^S2 tim^SL tim^UL to¹ vri¹ vri^k05901 vri^Scer\UAS.cBa
Constructs (1)
	P{UAS-vri.B}
Genes (23)
	CkIIβ Clk CrebB Crg-1 cry cyc dco dnc E(spl)m8-HLH lark Nf1 numb Pdf per Pka-C1 Pka-R2 Reg-5 rl sgg tim timeout to vri