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Citation
Stanewsky, R. (2003). Genetic analysis of the circadian system in Drosophila melanogaster and mammals.  J. Neurobiol. 54(1): 111--147.
FlyBase ID
FBrf0155881
Publication Type
Review
Abstract

The fruit fly, Drosophila melanogaster, has been a grateful object for circadian rhythm researchers over several decades. Behavioral, genetic, and molecular studies helped to reveal the genetic bases of circadian time keeping and rhythmic behaviors. Contrary, mammalian rhythm research until recently was mainly restricted to descriptive and physiologic approaches. As in many other areas of research, the surprising similarity of basic biologic principles between the little fly and our own species, boosted the progress of unraveling the genetic foundation of mammalian clock mechanisms. Once more, not only the basic mechanisms, but also the molecules involved in establishing our circadian system are taken or adapted from the fly. This review will try to give a comparative overview about the two systems, highlighting similarities as well as specifics of both insect and murine clocks.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Neurobiol.
    Title
    Journal of Neurobiology
    Publication Year
    1969-
    ISBN/ISSN
    0022-3034
    Data From Reference