Reference Report

Reference
Citation	Botella, J.A., Kretzschmar, D., Kiermayer, C., Feldmann, P., Hughes, D.A., Schneuwly, S. (2003). Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap. Mol. Biol. Cell 14(1): 241--250. (Export to RIS)
FlyBase ID	FBrf0155942
Publication Type	Research paper
PubMed ID	12529440
PubMed Abstract	Ras signaling has been shown to play an important role in promoting cell survival in many different tissues. Here we show that upregulation of Ras activity in adult Drosophila neurons induces neuronal cell death, as evident from the phenotype of vacuolar peduncle (vap) mutants defective in the Drosophila RasGAP gene, which encodes a Ras GTPase-activating protein. These mutants show age-related brain degeneration that is dependent on activation of the EGF receptor signaling pathway in adult neurons, leading to autophagic cell death (cell death type 2). These results provide the first evidence for a requirement of Egf receptor activity in differentiated adult Drosophila neurons and show that a delicate balance of Ras activity is essential for the survival of adult neurons.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mol. Biol. Cell
Title	Molecular Biology of the Cell
Publication Year	1992-
ISBN/ISSN	1059-1524
Data from Reference
Alleles (19)
	drk^k02401 Egfr^f3 Egfr^tsla Egfr^WT.hs Ras85D^Scer\UAS.cKa Ras85D^{V12.C40.Scer\UAS} Ras85D^{V12.G37.Scer\UAS} Ras85D^{V12.S35.Scer\UAS} Ras85D^V12.Scer\UAS Ras85D^ΔC40B RasGAP1^EP45 rho^hs.PSt Scer\GAL4^Appl.G1a Scer\GAL4^elav-C155 sty^S73 vap² vap³ vap^KS67 vap^{Scer\UAS.T:Hsap\MYC}
Constructs (10)
	?{} P{Appl-GAL4.G1a} P{hs-Egfr.wt} P{HS-rho} P{UAS-Ras85D.K} P{UAS-Ras85D.V12.C40} P{UAS-Ras85D.V12.G37} P{UAS-Ras85D.V12.S35} P{UAS-Ras85D.V12} P{UAS-RasGAP.Myc}
Genes (11)
	Csp drk Egfr elav Ras85D RasGAP1 rho Scer\GAL4 sty T:Hsap\MYC vap
Insertions (4)
	?{}vap³ P{EP}RasGAP1^EP45 P{GawB}elav^C155 P{lacW}drk^k02401