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Reference
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| Citation |
Bello, B.C., Hirth, F., Gould, A.P. (2003). A pulse of the Drosophila Hox protein Abdominal-A schedules the end of neural proliferation via neuroblast apoptosis. Neuron 37(2): 209--219. |
| FlyBase ID |
FBrf0156017 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
12546817 |
| PubMed Abstract |
Postembryonic neuroblasts are stem cell-like precursors that generate most neurons of the adult Drosophila central nervous
system (CNS). Their capacity to divide is modulated along the anterior-posterior body axis, but the mechanism underlying this
is unclear. We use clonal analysis of identified precursors in the abdomen to show that neuron production stops because the
cell death program is activated in the neuroblast while it is still engaged in the cell cycle. A burst of expression of the
Hox protein Abdominal-A (AbdA) specifies the time at which apoptosis occurs, thereby determining the final number of progeny
that each neuroblast generates. These studies identify a mechanism linking the Hox axial patterning system to neural proliferation,
and this involves temporal regulation of precursor cell death rather than the cell cycle.
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| Biosis |
2003.117592 |
| Zoological record |
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Associated Information
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| Comments |
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| Text of personal communication |
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| Associated files |
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Related Publications
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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Published In
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| Abbreviation |
Neuron |
| Title |
Neuron |
| Authors |
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| Volume range |
1- |
| Year range |
1988- |
| Page range |
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| Publisher |
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| Place of publication |
Cambridge, MA |
| Language of publication |
English |
| ISBN/ISSN |
0896-6273 |
| CODEN |
NERNET |
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Data from Reference
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| Aberrations (1)
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| Alleles (12)
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| Constructs (9)
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| Genes (11)
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| Insertions (10)
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