Reference Report

Reference
Citation	Hummel, T., Vasconcelos, M.L., Clemens, J.C., Fishilevich, Y., Vosshall, L.B., Zipursky, S.L. (2003). Axonal targeting of olfactory receptor neurons in Drosophila is controlled by Dscam. Neuron 37(2): 221--231. (Export to RIS)
FlyBase ID	FBrf0156018
Publication Type	Research paper
PubMed ID	12546818
PubMed Abstract	Different classes of olfactory receptor neurons (ORNs) in Drosophila innervate distinct targets, or glomeruli, in the antennal lobe of the brain. Here we demonstrate that specific ORN classes require the cell surface protein Dscam (Down Syndrome Cell Adhesion Molecule) to synapse in the correct glomeruli. Dscam mutant ORNs frequently terminated in ectopic sites both within and outside the antennal lobe. The morphology of Dscam mutant axon terminals in either ectopic or cognate targets was abnormal. Target specificity for other ORNs was not altered in Dscam mutants, suggesting that different ORNs use different strategies to regulate wiring. Multiple forms of Dscam RNA were detected in the developing antenna, and Dscam protein was localized to developing ORN axons. We propose a role for Dscam protein diversity in regulating ORN target specificity.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Aberrations (1)
	Df(2R)cos-2
Alleles (15)
	Dscam²¹ Dscam²³ Dscam³³ Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} n-syb^{Scer\UAS.cEa.T:Avic\GFP} Scer\GAL4^elav-C155 Scer\GAL4^GH146 Scer\GAL4^GH298 Scer\GAL4^Or22a.7.717 Scer\GAL4^Or23a.7.818 Scer\GAL4^{Or46a.1.875.T:Hsim\VP22} Scer\GAL4^Or47a.8.239 Scer\GAL4^Or47b.7.467 Scer\GAL4^Or59c.PF Scer\GAL4^Or71a.PF
Constructs (9)
	P{Or22a-GAL4.7.717} P{Or23a-GAL4.7.818} P{Or46a-GAL4.1.875} P{Or47a-GAL4.8.239} P{Or47b-GAL4.7.467} P{Or59c-GAL4.F} P{Or71a-GAL4.F} P{UAS-mCD8::GFP.L} P{UAS-n-syb-GFP.E}
Genes (14)
	brp Dscam elav Mmus\Cd8a n-syb Or22a Or23a Or46a Or47a Or47b Or71a Scer\GAL4 T:Avic\GFP T:Hsim\VP22
Insertions (3)
	P{GawB}elav^C155 P{GawB}GH146 P{GawB}GH298
Transcripts (5)
	Scer\GAL4^Or22a.7.717RA Scer\GAL4^Or23a.7.818RA Scer\GAL4^{Or46a.1.875.T:Hsim\VP22}RA Scer\GAL4^Or47a.8.239RA Scer\GAL4^Or47b.7.467RA