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Citation
Tree, D.R.P., Ma, D., Axelrod, J.D. (2002). A three-tiered mechanism for regulation of planar cell polarity.  Semin. Cell Dev. Biol. 13(3): 217--224.
FlyBase ID
FBrf0156198
Publication Type
Review
Abstract

Some epithelial cells are polarized along an axis orthogonal to their apical-basal axes. Recent studies in Drosophila lead to the view that three classes of signaling molecules govern the planar cell polarity (PCP) pathway. The first class, or module, functions across whole tissues, providing directional information to individual cells. The second module, apparently shared by all planar polarized tissues, and related to the canonical Wnt signaling pathway, interprets the directional signal to produce subcellular asymmetries. The third modules are tissue specific, acting to translate subcellular asymmetry into the appropriate morphological manifestations in the different cell types.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Semin. Cell Dev. Biol.
    Title
    Seminars in cell and developmental biology
    Publication Year
    1996-
    ISBN/ISSN
    1084-9521
    Data From Reference
    Alleles (2)
    Genes (25)