Reference Report

Reference
Citation	Justice, N., Roegiers, F., Jan, L.Y., Jan, Y.N. (2003). Lethal giant larvae acts together with numb in Notch inhibition and cell fate specification in the Drosophila adult sensory organ precursor lineage. Curr. Biol. 13(9): 778--783. (Export to RIS)
FlyBase ID	FBrf0158820
Publication Type	Research paper
PubMed ID	12725738
PubMed Abstract	The tumor suppressor genes lethal giant larvae (lgl) and discs large (dlg) act together to maintain the apical basal polarity of epithelial cells in the Drosophila embryo. Neuroblasts that delaminate from the embryonic epithelium require lgl to promote formation of a basal Numb and Prospero crescent, which will be asymmetrically segregated to the basal daughter cell upon division to specify cell fate. Sensory organ precursors (SOPs) also segregate Numb asymmetrically at cell division. Numb functions to inhibit Notch signaling and to specify the fates of progenies of the SOP that constitute the cellular components of the adult sensory organ. We report here that, in contrast to the embryonic neuroblast, lgl is not required for asymmetric localization of Numb in the dividing SOP. Nevertheless, mosaic analysis reveals that lgl is required for cell fate specification within the SOP lineage; SOPs lacking Lgl fail to specify internal neurons and glia. Epistasis studies suggest that Lgl acts to inhibit Notch signaling by functioning downstream or in parallel with Numb. These findings uncover a previously unknown function of Lgl in the inhibition of Notch and reveal different modes of action by which Lgl can influence cell fate in the neuroblast and SOP lineages.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Curr. Biol.
Title	Current Biology
Publication Year	1991-
ISBN/ISSN	0960-9822
Data from Reference
Alleles (9)
	l(2)gl⁴ l(2)gl^4w3 l(2)gl^unspecified Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} N^l1N-ts1 numb² numb^{PTB.Scer\UAS.T:Avic\GFP} pon^{LD.Scer\UAS.T:Avic\GFP} Scer\GAL4^{neur-GAL4-A101}
Constructs (3)
	P{UAS-mCD8::GFP.L} P{UAS-numb.PTB.GFP} P{UAS-pon.GFP.LD}
Genes (11)
	AP-2α baz elav l(2)gl Mmus\Cd8a N numb pon pros Scer\GAL4 T:Avic\GFP
Insertions (1)
	P{GawB}neur^GAL4-A101