Reference Report

Reference
Citation	Kango-Singh, M., Singh, A., Sun, Y.H. (2003). Eyeless collaborates with Hedgehog and Decapentaplegic signaling in Drosophila eye induction. Dev. Biol. 256(1): 48--60. (Export to RIS)
FlyBase ID	FBrf0158852
Publication Type	Research paper
PubMed ID	12654291
PubMed Abstract	eyeless (ey) is a key regulator of the eye development pathway in Drosophila. Ectopic expression of ey can induce the expression of several eye-specification genes (eya, so, and dac) and induce eye formation in multiple locations on the body. However, ey does not induce eye formation everywhere where it is ectopically expressed, suggesting that EY needs to collaborate with additional factors for eye induction. We examined ectopic eye induction by EY in the wing disc and found that eye induction was spatially restricted to the posterior compartment and the anterior-posterior (A/P) compartmental border, suggesting a requirement for both HH and DPP signaling. Although EY in the anterior compartment induced dpp and dac, these were not sufficient for eye induction. Coexpression experiments show that EY needs to collaborate with high level of HH and DPP to induce ectopic eye formation. Ectopic eye formation also requires the activation of an eye-specific enhancer of the endogenous hh gene.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Alleles (18)
	Avic\GFP^{S65T.Scer\UAS} brk^Scer\UAS.cJa ci^{Ce-2.Scer\UAS.T:Ivir\HA1} ci^{Scer\UAS.T:Ivir\HA1} dpp^Scer\UAS.cSa Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^hh-P30 Ecol\lacZ^ptc-k02507 ey² ey^Scer\UAS.cHa hh^bar3 hh^Scer\UAS.cAa Scer\GAL4^30A Scer\GAL4^Act5C.PI Scer\GAL4^ap-md544 Scer\GAL4^bi-omb-Gal4 Scer\GAL4^dpp.blk1 Scer\GAL4^{Scer\FRT.Act5C}
Constructs (11)
	P{Act5C-GAL4} P{AyGAL4} P{BS3.0} P{GAL4-dpp.blk1} P{UAS-brk.J} P{UAS-ci.Ce-2.HA} P{UAS-ci.HA} P{UAS-dpp.S} P{UAS-ey.H} P{UAS-GFP.S65T} P{UAS-hh.A}
Genes (17)
	Avic\GFP brk ci dac dpp Ecol\lacZ elav en ey eya hh hth ptc Scer\GAL4 smo T:Ivir\HA1 wg
Insertions (5)
	P{AyGAL4}25 P{GawB}30A P{GawB}ap^md544 P{lacW}ptc^k02507 P{PZ}hh^P30