Reference Report

Reference
Citation	Yang, L., Baker, N.E. (2003). Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye. Dev. Cell 4(3): 359--369. (Export to RIS)
FlyBase ID	FBrf0158858
Publication Type	Research paper
PubMed ID	12636917
PubMed Abstract	Receptor tyrosine kinases such as the EGF receptor transduce extracellular signals into multiple cellular responses. In the developing Drosophila eye, EGFR activity triggers cell differentiation. Here we focus on three additional cell autonomous aspects of EGFR function and their coordination with differentiation, namely, withdrawal from the cell cycle, mitosis, and cell survival. We find that, whereas differentiation requires intense signaling, dependent on multiple reinforcing ligands, lesser EGFR activity maintains cell cycle arrest, promotes mitosis, and protects against cell death. Each response requires the same Ras, Raf, MAPK, and Pnt signal transduction pathway. Mitotic and survival responses also involve Pnt-independent branches, perhaps explaining how survival and mitosis can occur independently. Our results suggest that, rather than triggering all or none responses, EGFR coordinates partially independent processes as the eye differentiates.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
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Data from Reference
Aberrations (1)
	Df(3L)γ3
Alleles (25)
	BacA\p35^GMR.PH Egfr^1.Scer\UAS Egfr^2.Scer\UAS Egfr⁰³⁰³³ Egfr⁰⁵³⁵¹ Egfr^f24 Egfr^top-18A Egfr^unspecified InR^Scer\UAS.cHa phl¹¹ Pi3K21B^{Scer\UAS.Δ.T:Ivir\HA1} Pi3K92E^{Scer\UAS.T:Hsap\MYC} pnt^05484Δ33 pnt^07825Δ78 pnt^Δ88 Ras85D^{V12.C40.Scer\UAS} Ras85D^{V12.G37.Scer\UAS} Ras85D^{V12.S35.Scer\UAS} Ras85D^V12.Scer\UAS Ras85D^ΔC40B rho^7M43 ru¹ Scer\GAL4^GMR.PF spi^s.Scer\UAS spi^SC1
Constructs (12)
	P{Egfr.1.UAS} P{Egfr.2.UAS} P{GAL4-ninaE.GMR} P{GMRP35} P{UAS-InR.H} P{UAS-Pi3K21BΔ.HA} P{UAS-Ras85D.V12.C40} P{UAS-Ras85D.V12.G37} P{UAS-Ras85D.V12.S35} P{UAS-Ras85D.V12} P{UAS-spi.s} P{WT-Dp110}
Genes (20)
	BacA\p35 CycB Egfr elav Ice InR phl Pi3K21B Pi3K92E pnt Ras85D rho rl ru Scer\GAL4 sens spi T:Hsap\MYC T:Ivir\HA1 vn
Insertions (2)
	P{PZ}Egfr⁰³⁰³³ P{PZ}Egfr⁰⁵³⁵¹