Reference Report

Reference
Citation	Hewes, R.S., Park, D., Gauthier, S.A., Schaefer, A.M., Taghert, P.H. (2003). The bHLH protein dimmed controls neuroendocrine cell differentiation in Drosophila. Development 130(9): 1771--1781. (Export to RIS)
FlyBase ID	FBrf0158877
Publication Type	Research paper
PubMed ID	12642483
PubMed Abstract	Neuroendocrine cells are specialized to produce, maintain and release large stores of secretory peptides. We show that the Drosophila dimmed/Mist1 bHLH gene confers such a pro-secretory phenotype on neuroendocrine cells. dimmed is expressed selectively in central and peripheral neuroendocrine cells. In dimmed mutants, these cells survive, and adopt normal cell fates and morphology. However, they display greatly diminished levels of secretory peptide mRNAs, and of diverse peptides and proteins destined for regulated secretion. Secretory peptide levels are lowered even in the presence of artificially high secretory peptide mRNA levels. In addition, overexpression of dimmed in a wild-type background produces a complimentary phenotype: an increase in secretory peptide levels by neuroendocrine cells, and an increase in the number of cells displaying a neuroendocrine phenotype. We propose that dimmed encodes an integral component of a novel mechanism by which diverse neuroendocrine lineages differentiate and maintain the pro-secretory state.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (5)
	Df(2L)crc^R2 Df(2L)crc^R6 Df(2L)Rev4 Df(2L)Rev8 Df(2L)Rev18
Alleles (18)
	Btau\MAPT^{Scer\UAS.T:Hsap\MYC} crc¹ crc⁹²⁹ crc^R2 crc^R6 dimm⁹²⁹ dimm^dsRNA.cHa dimm^KG02598 dimm^R6 dimm^Rev8 dimm^{Scer\UAS.T:Hsap\MYC} Ecol\lacZ^Scer\UAS.cBa Gr39a⁰⁶³¹¹ Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Pdf^Scer\UAS.cRa Scer\GAL4^ap-md544 Scer\GAL4^c127 Scer\GAL4^dimm-929
Constructs (5)
	P{UAS-btau.T:Myc} P{UAS-dimm.MYC} P{UAS-lacZ.B} P{UAS-mCD8::GFP.L} P{UAS-Pdf.R}
Genes (16)
	Btau\MAPT Ccap crc Crz dimm Ecol\lacZ Fmrf Fur1 Gr39a Lk Mio Mmus\Cd8a Pdf Phm Scer\GAL4 T:Hsap\MYC
Insertions (8)
	P{GawB}ap^md544 P{GawB}c127 P{GawB}dimm⁹²⁹ P{PZ}Gr39a⁰⁶³¹¹ P{SUPor-P}dimm^KG02598 P{UAS-dimm.MYC}2-A-3 P{UAS-GFP.Y}B1 P{UAS-lacZ.B}melt^Bg4-1-2