Reference Report

Reference
Citation	Rawls, A.S., Wolff, T. (2003). Strabismus requires Flamingo and Prickle function to regulate tissue polarity in the Drosophila eye. Development 130(9): 1877--1887. (Export to RIS)
FlyBase ID	FBrf0158881
Publication Type	Research paper
PubMed ID	12642492
PubMed Abstract	Tissue polarity in Drosophila is regulated by a number of genes that are thought to function in a complex, many of which interact genetically and/or physically, co-localize, and require other tissue polarity proteins for their localization. We report the enhancement of the strabismus tissue polarity phenotype by mutations in two other tissue polarity genes, flamingo and prickle. Flamingo is autonomously required for the establishment of ommatidial polarity. Its localization is dynamic throughout ommatidial development and is dependent on Frizzled and Notch. Flamingo and Strabismus co-localize for several rows posterior to the morphogenetic furrow and subsequently diverge. While neither of these proteins is required for the other's localization, Prickle localization is influenced by Strabismus function. Our data suggest that Strabismus, Flamingo and Prickle function together to regulate the establishment of tissue polarity in the Drosophila eye.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (6)
	Df(2L)N22-14 Df(2L)s1402 Df(2R)Drl^rv5 Df(2R)E3363 Df(2R)Jp4 Df(2R)pk78k
Alleles (13)
	fz³⁷ hk¹¹ N^l1N-ts1 pk¹ pk^eq shi² stan¹⁹² stan^E59 stan^frz3 Vang^sev.PR Vang^stbm-6 Vang^stbm-153 W^GMR.PG
Constructs (2)
	P{GMR-hid} P{sev-stbm.R}
Genes (9)
	arm fz hk N pk shi stan Vang W