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Reference
Citation
Hader, T., Muller, S., Aguilera, M., Eulenberg, K.G., Steuernagel, A., Ciossek, T., Kuhnlein, R.P., Lemaire, L., Fritsch, R., Dohrmann, C., Vetter, I.R., Jackle, H., Doane, W.W., Bronner, G. (2003). Control of triglyceride storage by a WD40/TPR-domain protein.  EMBO Rep. 4(5): 511--516.
FlyBase ID
FBrf0158903
Publication Type
Research paper
Abstract

Obesity is a metabolic disorder related to improper control of energy uptake and expenditure, which results in excessive accumulation of body fat. Initial insights into the genetic pathways that regulate energy metabolism have been provided by a discrete number of obesity-related genes that have been identified in mammals. Here, we report the identification of the adipose (adp) gene, the mutation of which causes obesity in Drosophila. Loss of adp activity promotes increased fat storage, which extends the lifespan of mutant flies under starvation conditions. By contrast, adp gain-of-function causes a specific reduction of the fat body in Drosophila. adp encodes an evolutionarily conserved WD40/tetratricopeptide-repeat-domain protein that is likely to represent an intermediate in a novel signalling pathway.

PubMed ID
PubMed Central ID
PMC1319192 (PMC) (EuropePMC)
Associated Information
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    EMBO Rep.
    Title
    EMBO Reports
    Publication Year
    2000-
    ISBN/ISSN
    1469-221X 1469-3178
    Data From Reference
    Aberrations (1)
    Alleles (7)
    Genes (3)
    Human Disease Models (1)
    Natural transposons (1)
    Insertions (3)
    Experimental Tools (1)
    Transgenic Constructs (2)