Reference Report

Reference
Citation	Blanton, J., Gaszner, M., Schedl, P. (2003). Protein:protein interactions and the pairing of boundary elements in vivo. Genes Dev. 17(5): 664--675. (Export to RIS)
FlyBase ID	FBrf0158943
Publication Type	Review
PubMed ID	12629048
PubMed Abstract	Although it is now well-established that boundary elements/insulators function to subdivide eukaryotic chromosomes into autonomous regulatory domains, the underlying mechanisms remain elusive. One idea is that boundaries act as barriers, preventing the processive spreading of "active" or "silenced" chromatin between domains. Another is that the partitioning into autonomous functional units is a consequence of an underlying structural subdivision of the chromosome into higher order "looped" domains. In this view, boundaries are thought to delimit structural domains by interacting with each other or with some other nuclear structure. The studies reported here provide support for the looped domain model. We show that the Drosophila scs and scs' boundary proteins, Zw5 and BEAF, respectively, interact with each other in vitro and in vivo. Moreover, consistent with idea that this protein:protein interaction might facilitate pairing of boundary elements, we find that that scs and scs' are in close proximity to each other in Drosophila nuclei.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Aberrations (1)
	Df(1)JC19
Alleles (5)
	BEAF-32^Scer\UAS.cYa dwg⁸ dwg⁹⁰ dwg^Hsp83.PG Scer\GAL4^GMR.PF
Constructs (2)
	P{GAL4-ninaE.GMR} P{Hsp83-dwg.G}
Genes (5)
	BEAF-32 dwg Scer\GAL4 scs scs'
Insertions (1)
	P{Hsp83-dwg.G}17.1.1