Reference Report

Reference
Citation	Shareef, M.M., Badugu, R., Kellum, R. (2003). HP1/ORC complex and heterochromatin assembly. Genetica 117(2-3): 127--134. (Export to RIS)
FlyBase ID	FBrf0158957
Publication Type	Review
PubMed ID	12723692
PubMed Abstract	We have used the highly conserved heterochromatin component, heterochromatin protein 1 (HP1), as a molecular tag for purifying other protein components of Drosophila heterochromatin. A complex of HP1 associated with the origin recognition complex (ORC) and an HP1/ORC-associated protein (HOAP) was purified from the maternally loaded cytoplasm of early Drosophila embryo. We propose that the DNA-binding activities of ORC and HOAP function to recruit underphosphorylatedisoforms of HP1 to sites of heterochromatin nucleation. The roles of highly phosphorylated HP1, other DNA-binding proteins known to interact with HP1, and histone modifying activities in heterochromatin assembly are also addressed.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genetica
Title	Genetica
Publication Year	1919-
ISBN/ISSN	0016-6707
Data from Reference
Genes (5)
	cav Orc2 Orc6 Su(var)3-9 Su(var)205