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Citation
Tritto, P., Specchia, V., Fanti, L., Berloco, M., D'Alessandro, R., Pimpinelli, S., Palumbo, G., Bozzetti, M.P. (2003). Structure, regulation and evolution of the crystal-Stellate system of Drosophila.  Genetica 117(2-3): 247--257.
FlyBase ID
FBrf0158965
Publication Type
Research paper
Abstract
The crystal-Stellate system is one of the most known example of interaction between heterochromatin and euchromatin: a heterochromatic locus on the Y chromosome (crystal) 'represses' a euchromatic locus (Stellate) on the X chromosome in Drosophila melanogaster. The molecular mechanism regulating this interaction is not completely understood. It is becoming clear that an RNA interference (RNAi) mechanism could be responsible for the silencing carried out by crystal on the Stellate sequences. Here, a detailed structural analysis of all the sequences involved in the system is reported, demonstrating a their 'puzzling' structure. In addition three autosomal mutations: sting, scratch and sirio are described that interfere with the system. All of them are male sterile mutations and exhibit crystals made by the STELLATE protein in their primary spermatocytes. They are requested during oogenesis and early in embryogenesis as well. Hypothesis on the involvement of these genes in activating the Stellate sequences are discussed.
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetica
    Title
    Genetica
    Publication Year
    1919-
    ISBN/ISSN
    0016-6707
    Data From Reference
    Aberrations (1)
    Alleles (6)
    Genes (12)
    Natural transposons (3)
    Insertions (2)