Reference Report

Reference
Citation	Scott, E.K., Reuter, J.E., Luo, L. (2003). Small GTPase Cdc42 is required for multiple aspects of dendritic morphogenesis. J. Neurosci. 23(8): 3118--3123. (Export to RIS)
FlyBase ID	FBrf0159064
Publication Type	Research paper
PubMed ID	12716918
PubMed Abstract	The study of dendritic development in CNS neurons has been hampered by a lack of complex dendritic structures that can be studied in a tractable genetic system. In an effort to develop such a system, we recently characterized the highly complex dendrites of the vertical system (VS) neurons in the Drosophila visual system. Using VS neurons as a model system, we show here using loss-of-function mutations that endogenous Cdc42, a member of Rho family of small GTPases, is required for multiple aspects of dendritic morphogenesis. Cdc42-mutant VS neurons display normal complexity but increased dendritic length compared with wild type and have defects in dendrite caliber and stereotyped dendritic branch positions. Remarkably, Cdc42 mutant neurons also show a 50% reduction in dendritic spine density. These results demonstrate that Cdc42 is a regulator for multiple aspects of dendritic development.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	J. Neurosci.
Title	Journal of Neuroscience
Publication Year	1981-
ISBN/ISSN	0270-6474 1529-2401
Data from Reference
Alleles (6)
	Act5C^{Scer\UAS.T:Avic\GFP} Cdc42³ Cdc42⁴ Cdc42^Scer\UAS.cLa Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^elav.PLu
Constructs (4)
	P{GAL4-elav.L} P{UAS-Act5C.T:GFP} P{UAS-Cdc42.L} P{UAS-mCD8::GFP.L}
Genes (5)
	Act5C Cdc42 Mmus\Cd8a Scer\GAL4 T:Avic\GFP