Reference Report

Reference
Citation	Sugimura, K., Yamamoto, M., Niwa, R., Satoh, D., Goto, S., Taniguchi, M., Hayashi, S., Uemura, T. (2003). Distinct developmental modes and lesion-induced reactions of dendrites of two classes of Drosophila sensory neurons. J. Neurosci. 23(9): 3752--3760. (Export to RIS)
FlyBase ID	FBrf0159066
Publication Type	Research paper
PubMed ID	12736346
PubMed Abstract	Little has been understood about the underlying mechanisms that generate the morphological diversity of dendritic trees. Dendritic arborization neurons in Drosophila provide an excellent model system to tackle this question, and they are classified into classes I-IV in order of increasing arbor complexity. Here we have developed transgenic green fluorescent protein markers for class I or class IV cells, which allowed time-lapse recordings of dendritic birth in the embryo, its maturation processes in the larva, and lesion-induced reactions. The two classes used distinct strategies of dendritic emergence from the cell body and branching, which contributed to differences in their basic arbor patterns. In contrast to the class I cells examined, one cell of class IV, which was a focus in this study, continued to elaborate branches throughout larval stages, and it was much more capable of responding to the severing of branches. We also investigated the cellular basis of field formation between adjacent class IV cells. Our results support the fact that class-specific inhibitory interaction is necessary and sufficient for tiling and confirmed that this intercellular communication was at work at individual dendrodendritic interfaces. Finally, this inhibitory signaling appeared to play a central role when arbors of adjacent cells started meeting midway between the cells and until the body wall became partitioned into abutting, minimal-overlapping territories.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	J. Neurosci.
Title	Journal of Neuroscience
Publication Year	1981-
ISBN/ISSN	0270-6474 1529-2401
Data from Reference
Alleles (12)
	Act5C^{Scer\UAS.T:Avic\GFP} Avic\GFP^{S65T.Scer\UAS} Avic\GFP^{Scer\UAS.T:Btau\MAPT} Avic\GFP^{Scer\UAS.T:Ecol\lacZ,T:SV40\nls2} Avic\GFP^{Venus.Scer\UAS.T:Hsap\pm} Avic\GFP^{Venus.Scer\UAS} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^IG1-1 Scer\GAL4^IG1-2 Scer\GAL4^NP2225 Scer\GAL4^NP7028 w^+mC
Constructs (7)
	P{UAS-Act5C.T:GFP} P{UAS-GFP::lacZ.nls} P{UAS-GFP.btau} P{UAS-GFP.S65T} P{UAS-mCD8::GFP.L} P{UAS-Venus.pm} P{UAS-Venus}
Genes (10)
	Act5C Avic\GFP Mmus\Cd8a Scer\GAL4 T:Avic\GFP T:Btau\MAPT T:Ecol\lacZ T:Hsap\pm T:SV40\nls2 w
Insertions (4)
	P{GawB}ab^NP2225 P{GawB}IG1-1 P{GawB}IG1-2 P{GawB}NP7028