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Citation
Jacinto, E., Hall, M.N. (2003). TOR signalling in bugs, brain and brawn.  Nat. Rev. Mol. Cell Biol. 4(2): 117--126.
FlyBase ID
FBrf0159230
Publication Type
Review
Abstract

TOR--a highly conserved atypical protein kinase and the 'target of rapamycin', an immunosuppressant and anti-cancer drug--controls cell growth. TOR controls the growth of proliferating yeast, fly and mammalian cells in response to nutrients. Recent findings, however, indicate that TOR also controls the growth of non-proliferating cells, such as neurons and muscle cells. Furthermore, TOR, by associating with regulatory proteins and inhibiting phosphatases, controls the activity of multiphosphorylated effectors.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Rev. Mol. Cell Biol.
    Title
    Nature Reviews. Molecular Cell Biology
    Publication Year
    2000-
    ISBN/ISSN
    1471-0072
    Data From Reference
    Genes (12)