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| Citation | Leulier, F., Parquet, C., Pili-Floury, S., Ryu, J.H., Caroff, M., Lee, W.J., Mengin-Lecreulx, D., Lemaitre, B. (2003). The Drosophila immune system detects bacteria through specific peptidoglycan recognition. Nat. Immunol. 4(5): 478--484. (Export to RIS) | ||
| FlyBase ID | FBrf0159245 | ||
| Publication Type | Research paper | ||
| PubMed ID | 12692550 | ||
| PubMed Abstract | The Drosophila immune system discriminates between different classes of infectious microbes and responds with pathogen-specific defense reactions through selective activation of the Toll and the immune deficiency (Imd) signaling pathways. The Toll pathway mediates most defenses against Gram-positive bacteria and fungi, whereas the Imd pathway is required to resist infection by Gram-negative bacteria. The bacterial components recognized by these pathways remain to be defined. Here we report that Gram-negative diaminopimelic acid-type peptidoglycan is the most potent inducer of the Imd pathway and that the Toll pathway is predominantly activated by Gram-positive lysine-type peptidoglycan. Thus, the ability of Drosophila to discriminate between Gram-positive and Gram-negative bacteria relies on the recognition of specific forms of peptidoglycan. | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Nat. Immunol. | ||
| Title | Nature Immunology | ||
| Publication Year | 2000- | ||
| ISBN/ISSN | 1529-2908 1529-2916 | ||
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Data from Reference
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