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Reference Report
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| Citation | Kim, S., Shi, H., Lee, D.K., Lis, J.T. (2003). Specific SR protein-dependent splicing substrates identified through genomic SELEX. Nucleic Acids Res. 31(7): 1955--1961. (Export to RIS) | ||
| FlyBase ID | FBrf0159267 | ||
| Publication Type | Research paper | ||
| PubMed ID | 12655012 | ||
| PubMed Abstract | The Drosophila pre-mRNA splicing factor B52 (SRp55) is essential for fly development, but splicing of RNAs of specific genes tested previously is normal in B52-null animals, presumably due to partial functional redundancy with other SR proteins. To identify B52-dependent splicing substrates in vivo, we selected genomic sequence fragments whose transcripts bind B52. Almost all of the corresponding genes having a known function encode either transcription factors or components of signal transduction pathways, with the B52- binding fragments located to not only exonic but also intronic regions. Some pre-mRNAs from these genes showed splicing defects in the B52-null mutant. These results indicate that B52 has unique functions in the removal of some introns during development, and plays a critical role in cellular regulatory networks. | ||
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| All updates | Click here to see a list of all updates to this record from FB2010_08 and on. | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Nucleic Acids Res. | ||
| Title | Nucleic Acids Research | ||
| Publication Year | 1974- | ||
| ISBN/ISSN | 0305-1048 | ||
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Data from Reference
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| Alleles (1)
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| Genes (22)
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| Natural transposons (4)
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