|Citation||Kim, S., Shi, H., Lee, D.K., Lis, J.T. (2003). Specific SR protein-dependent splicing substrates identified through genomic SELEX. Nucleic Acids Res. 31(7): 1955--1961. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||The Drosophila pre-mRNA splicing factor B52 (SRp55) is essential for fly development, but splicing of RNAs of specific genes tested previously is normal in B52-null animals, presumably due to partial functional redundancy with other SR proteins. To identify B52-dependent splicing substrates in vivo, we selected genomic sequence fragments whose transcripts bind B52. Almost all of the corresponding genes having a known function encode either transcription factors or components of signal transduction pathways, with the B52- binding fragments located to not only exonic but also intronic regions. Some pre-mRNAs from these genes showed splicing defects in the B52-null mutant. These results indicate that B52 has unique functions in the removal of some introns during development, and plays a critical role in cellular regulatory networks.|
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|Language of Publication||English|
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|Abbreviation||Nucleic Acids Res.|
|Title||Nucleic Acids Research|
|Data from Reference|
|Natural transposons (4)|