Reference Report

Reference
Citation	Crowner, D., Le Gall, M., Gates, M.A., Giniger, E. (2003). Notch Steers Drosophila ISNb Motor Axons by Regulating the Abl Signaling Pathway. Curr. Biol. 13(11): 967--972. (Export to RIS)
FlyBase ID	FBrf0159717
Publication Type	Research paper
External Crossreferences
PubMed ID	12781136
PubMed Abstract	The central problem in axon guidance is to understand how guidance signals interact to determine where an axon will grow. Here we investigate a specific axon guidance decision in Drosophila embryos, the sharp inward turn taken by the ISNb motor nerve to approach its muscle targets. We find that this turn requires Notch and its ligand Delta. We show that Delta is expressed on cells adjacent to the ISNb turning point, and we know from previous work that Notch is present on axonal growth cones, suggesting that Delta and Notch might provide a guidance signal to ISNb. To induce the turning of ISNb axons, Notch interacts genetically with multiple components of a signal transduction pathway that includes the Abl tyrosine kinase and its affiliated accessory proteins. In contrast, genetic interaction experiments fail to provide evidence for a major role of the "canonical" Notch/Su(H) signaling pathway in this process. We suggest that the Notch/Abl interaction promotes the turning of ISNb axons by attenuating the Abl-dependent adhesion of ISNb axons to their substratum, thus releasing the axons to respond to attraction from target muscles.
BIOSIS ID	2003.384257
Zoological Record ID
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Associated Information
Comments
Text of Personal Communication
Associated Files
Related Publications
Personal communication to FlyBase	UAS-Dl, nrt<up>M54</up>, trio<up>123.4</up> and sim-GAL4. Giniger, 2003.7.28, UAS-Dl, nrt<up>M54</up>, trio<up>123.4</up> and sim-GAL4. [FBrf0159722]
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
ISBN
Parent Publication
Publication Type	Journal
Abbreviation	Curr. Biol.
Title	Current Biology
Editors
Publication Year	1991-
ISBN/ISSN	0960-9822
Data from Reference
Aberrations (1)
	Df(3L)st-j7
Alleles (19)
	Abl¹ Abl^Scer\UAS.cFa btl^unspecified Dl^6B Dl^Scer\UAS.cDa Dl^vi1 ena^GC1 ena^GC5 gcm^unspecified mam²³ N^l1N-ts1 N^Scer\UAS.cBa Nrt^M54 Scer\GAL4^btl.PS Scer\GAL4^elav.PLu Scer\GAL4^sim.P3.7 Scer\GAL4^unspecified Su(H)² trio^123.4
Constructs (5)
	P{GAL4-btl.S} P{GAL4-elav.L} P{GAL4-sim.3.7} P{UAS-Abl.F} P{UAS-N.Ba}
Genes (12)
	Abl btl Dl ena gcm mam N Nrt repo Scer\GAL4 Su(H) trio