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Citation
Zhao, J., Kilman, V.L., Keegan, K.P., Peng, Y., Emery, P., Rosbash, M., Allada, R. (2003). Drosophila clock can generate ectopic circadian clocks.  Cell 113(6): 755--766.
FlyBase ID
FBrf0159721
Publication Type
Research paper
Abstract

Circadian rhythms of behavior, physiology, and gene expression are present in diverse tissues and organisms. The function of the transcriptional activator, Clock, is necessary in both Drosophila and mammals for the expression of many core clock components. We demonstrate in Drosophila that Clock misexpression in nai;ve brain regions induces circadian gene expression. This includes major components of the pacemaker program, as Clock also activates the rhythmic expression of cryptochrome, a gene that CLOCK normally represses. Moreover, this ectopic clock expression has potent effects on behavior, radically altering locomotor activity patterns. We propose that Clock is uniquely able to induce and organize the core elements of interdependent feedback loops necessary for circadian rhythms.

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Related Publication(s)
Review

Flies get rhythm.
Pilcher, 2003, Nature 423(6943): 935 [FBrf0159843]

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference