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Citation
Juhasz, G., Csikos, G., Sinka, R., Erdelyi, M., Sass, M. (2003). The Drosophila homolog of Aut1 is essential for autophagy and development.  FEBS Lett. 543(1-3): 154--158.
FlyBase ID
FBrf0159857
Publication Type
Research paper
Abstract
The Drosophila homolog of yeast Aut1, CG6877/Draut1, is a ubiquitously expressed cytosolic protein. Draut1 loss of function was achieved by expression of an inverted repeat transgene inducing RNA interference. The effect is temperature-dependent and resembles an allelic series as described by Fortier, E. and Belote, J.M. (Genesis 26 (2000) 240-244). Draut1 loss of function larvae are unable to induce autophagy and heterophagy in fat body cells before pupariation and die during metamorphosis. To our knowledge, this is the first report of a multicellular animal lacking the function of a gene participating in the protein conjugation systems of autophagy.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    FEBS Lett.
    Title
    FEBS Letters
    Publication Year
    1968-
    ISBN/ISSN
    0014-5793
    Data From Reference
    Aberrations (1)
    Alleles (5)
    Genes (3)
    Experimental Tools (2)
    Transgenic Constructs (4)