Reference Report

Reference
Citation	Balakirev, E.S., Chechetkin, V.R., Lobzin, V.V., Ayala, F.J. (2003). DNA polymorphism in the -Esterase gene cluster of Drosophila melanogaster. Genetics 164(2): 533--544. (Export to RIS)
FlyBase ID	FBrf0160393
Publication Type	Research paper
PubMed ID	12807774
PubMed Abstract	We have analyzed nucleotide polymorphism within a 5.3-kb region encompassing the functional Est-6 gene and the psiEst-6 putative pseudogene in 28 strains of Drosophila melanogaster and one of D. simulans. Two divergent sequence types were detected, which are not perfectly associated with Est-6 allozyme variation. The level of variation (pi) is very close in the 5'-flanking region (0.0059) and Est-6 gene (0.0057), but significantly higher in the intergenic region (0.0141) and putative pseudogene (0.0122). The variation in the 3'-flanking region is intermediate (0.0083). These observations may reflect different levels of purifying selection in the different regions. Strong linkage disequilibrium occurs within the region studied, with the largest values revealed in the putative pseudogene and 3'-flanking region. Moreover, recombination is restricted within psiEst-6. Gene conversion is detected both within and (to a lesser extent) between Est-6 and psiEst-6. The data indicate that psiEst-6 exhibits some characteristics that are typical of nonfunctional genes, while other characteristics are typically attributed to functional genes; the same situation has been observed in other pseudogenes (including Drosophila). The results of structural entropy analysis demonstrate higher structural ordering in Est-6 than in psiEst-6, in accordance with expectations if psiEst-6 is indeed a pseudogene. Taking into account that the function of psiEst-6 is not known (but could exist) and following the terminology of J. Brosius and S. J. Gould, we suggest that the term "potogene" may be appropriate for psiEst-6, indicating that it is a potential gene that may have acquired some distinctive but unknown function.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Alleles (28)
	Est-P^94F Est-P^174F Est-P^255S Est-P^357F Est-P^377F Est-P^510S Est-P^521F Est-P^521S Est-P^581F Est-P^968F Est-P^F-96S Est-P^F-274F Est-P^F-517F Est-P^F-517S Est-P^F-531F Est-P^F-611F Est-P^F-775F Est-P^F-1461S Est-P^S-5F Est-P^S-26F Est-P^S-114S Est-P^S-438S Est-P^S-483F Est-P^S-501S Est-P^S-549S Est-P^S-565F Est-P^S-1224F Est-P^US-255F
Genes (4)
	Dsim\Est-6 Dsim\Est-P Est-6 Est-P
Natural transposons (1)
	mdg3